Nervous System Diseases

1,005 trials 421 recruiting

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Open Label Extension Clinical Trial of Vormatrigine in Adult Patients with Epilepsy. Recruiting

2025-521640-38-00 Focal onset seizures or primary generalized tonic-cloni 5 2025-10-16
Examining the effects of intravenous oxytocin infusion on peripheral sensory afferents using microneurography technique in healthy volunteer… Recruiting

2024-519670-39-00 Healthy participants 3 2025-10-13
The effect of amantadine as add-on therapy for motor fluctuations in advanced Parkinson’s disease: a randomized double-blinded placebo-contr… Recruiting

2023-509728-16-00 advanced Parkinson’s disease 4 2025-10-10
A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial of Descartes-08 in Patients With Generalized Myasthenia Gravis (MG) Recruiting

2024-520355-25-00 generalized myasthenia gravis 5 2025-10-10
A confirmatory study to assess the efficacy of CEREBROLYSIN in post-acute ischemic stroke recovery Recruiting

2025-521350-41-01 Stroke 5 2025-10-10
Efficacy and safety of remibrutinib after switching from ocrelizumab in participants living with relapsing multiple sclerosis, followed by o… Recruiting

2023-509275-17-00 Relapsing multiple sclerosis 5 2025-10-06
A clinical trial to evaluate efficacy and safety of Xeomin® injections for preventing chronic migraine Recruiting

2024-515682-34-00 Chronic migraine 5 2025-10-06
A clinical trial to evaluate efficacy and safety of Xeomin® injections for preventing episodic migraine Recruiting

2024-515715-22-00 Episodic migraine 5 2025-10-06
A clinical study of MK-2214 in people with Alzheimer’s disease (MK-2214-004) Recruiting

2024-519190-19-00 Alzheimer’s Disease 4 2025-10-03
Safety, Tolerability and Biomarker-based Efficacy of NPI-001 (AT-001) in Subjects with Alzheimer’s Disease (AD) Recruiting

2024-519497-39-00 Alzheimer's Disease 4 2025-10-03
PDH-RAVICTI - A PHASE II, MULTICENTRIC, PROSPECTIVE, NON-COMPARATIVE CLINICAL TRIAL TO ASSESS THE EFFICACY AND SAFETY OF THE TREATMENT OF PY… Recruiting

2024-516410-38-00 Pyruvate dehydrogenase deficiency 4 2025-10-01
Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368, a FAAH/MAGL Inhibitor, in Participants with Multiple Sclerosis Spasti… Recruiting

2024-517745-14-00 Multiple Sclerosis Spasticity 4 2025-09-24
A phase 2 study of the effectiveness of golcadomide (CC-99282) for patients with large B-cell lymphoma in the brain Recruiting

2024-517051-12-00 Relapsed primary large B-cel lymphoma of the central ne 4 2025-09-16
A phase II randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of an oral solution of 9-Δ … Recruiting

2024-520287-34-01 Chronic neuropathic pain due to multiple sclerosis (MS) 4 2025-09-12
A study investigating the safety, tolerability, pharmacokinetics (absorption, distribution, metabolism and elimination) and effect of single… Recruiting

2025-522368-34-00 Alzheimer’s Disease 1 2025-09-05
Propofol injection pain in healthy adult participants Recruiting

2024-514307-34-01 Pain 4 2025-09-01
lmlifidase treatment tor acute inflammation in AQP4-lgG associated neuromyelitis optica spectrum disorder Recruiting

2024-517176-38-00 neuromyelitis optica spectrum disorder, devic disease 4 2025-08-31
A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia Recruiting

2025-520981-23-00 Idiopathic Hypersomnia (IH) 4 2025-08-26
A Phase 3, placebo-controlled study to investigate LP352 in children and adults with Developmental and Epileptic Encephalopathies Recruiting

2024-516412-17-00 Developmental and Epileptic Encephalopathies (DEE) 5 2025-08-26
Phase I, Open-Label Study to Evaluate the Pharmacokinetics, Safety and Tolerability of BIA 28-6156 in Participants with Varying Degrees of R… Recruiting

2025-520754-11-00 Parkinson's disease 3 2025-08-25
A Phase 2a, Multi-Center, Randomized, Parallel Group, Double Blind and Placebo-controlled Clinical Trial to Assess Safety and Tolerability a… Recruiting

2024-518563-35-00 Alzheimer's Disease 4 2025-08-25
A study to learn how safe zilucoplan is in children with generalized myasthenia gravis who participated in a previous study about zilucoplan Recruiting

2022-502073-42-00 Generalized Myasthenia Gravis 5 2025-08-18
Phase 0 trial of CBD in recurrent glioblastoma patients Recruiting

2024-513357-74-01 Glioblastoma 3 2025-08-04
Optimizing Reperfusion to Improve Outcomes and Neurologic Function (ORION) Recruiting

2024-519521-37-01 Acute ischemic stroke 10 2025-07-30