Nervous System Diseases

1,005 trials 421 recruiting

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A Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Safety, Tolerability, and Efficacy of TAK-360 in Participants with Na… Recruiting

2024-517711-70-01 Narcolepsy without Cataplexy (NT2) 4 2025-12-04
ACP-204 in Adults With Lewy Body Dementia Psychosis (LBDP) Recruiting

2025-521710-25-00 Lewy Body Dementia Psychosis (LBDP) 4 2025-12-04
Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2 Recruiting

2024-514763-25-01 spinocerebellar ataxia type 2 1 2025-12-04
Effects of goal-directed fluid management guided by a non-invasive device on the incidence of postoperative complications in neurosurgery: a… Recruiting

2024-511153-21-00 elective neurosurgery treating unspecified brain condit 6 2025-11-27
A dosimetry trial of uPAR targeted radioligand therapy in patients with glioblastoma Recruiting

2024-520105-39-00 Glioblastoma 3 2025-11-25
GAIN-CTNNB1: A Phase I/II open-label trial to evaluate the safety, tolerability, and preliminary efficacy of a single intracerebroventricula… Recruiting

2025-522719-40-00 CTNNB1 syndrome 7 2025-11-21
Foetal neural stem cells transplantation in progressive multiple sclerosis Recruiting

2024-511028-15-00 Progressive Multiple Sclerosis 4 2025-11-20
First-in-Human Study of ALN-SNCA in Adult Participants with Early Parkinson’s Disease (PD) Recruiting

2025-521431-37-00 Parkinson's disease 1 2025-11-20
A Phase Ib/II first-in-human, multicentre, open-label, multiple ascending dose study of S230815 in paediatric participants with KCNT1-relate… Recruiting

2024-513332-17-00 KCNT1-related Developmental and Epileptic Encephalopath 7 2025-11-19
Research into the safety of a new agent (NRG5051) in healthy adults and patients with Parkinson's disease or ALS Recruiting

2025-523872-22-00 Parkinsons's Disease and amyotrophic lateral sclerosis 1 2025-11-18
EUROpean pragmatic multicenter randomized trial on platelet inhibition and/or lipid lowering treatment in Covert Brain Infarction (CBI) Recruiting

2025-521452-30-01 Covert brain infarction (asymptomatic brain infarctions 5 2025-11-18
Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis Recruiting

2024-515979-35-00 Generalized Myasthenia Gravis 5 2025-11-13
A Efficacy and Safety Study of Trontinemab in Participants With Early Symptomatic Alzheimer’s Disease (MCI to Mild Dementia Due to AD) Recruiting

2024-518008-33-00 Early Symptomatic Alzheimer’s Disease (MCI to Mild Deme 5 2025-11-12
A 52-week, Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Study of Siplizumab in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (A… Recruiting

2023-506174-12-00 Amyotrophic Lateral Sclerosis 3 2025-11-06
Cangrelor in endovascular stroke treatment with emergent carotid artery stenting (CANCAS) Recruiting

2025-521564-35-00 ischemic stroke with intracranial large artery occlusio 4 2025-11-06
Longitudinal study with positron emission tomography using [18F]PI-2620 in primary tauopathies. Proof-of-concept study Recruiting

2025-522826-11-00 Corticobasal syndrome (CBS) 9 2025-11-06
A Phase 3b open-label, randomised study of IPX203 in subjects with advanced Parkinson’s disease and motor fluctuations - ADIP study Recruiting

2025-521772-57-00 Motor fluctuations in advanced Parkinson’s disease 5 2025-11-06
TAR-0520 Gel in taxanes-induced peripheral neuropathy Recruiting

2025-521674-33-00 Taxanes-induced peripheral neuropathy 4 2025-11-05
A first-in-human, randomized, double-blind, placebo-controlled, three-part study assessing the safety, tolerability, pharmacokinetics and ph… Recruiting

2025-521556-35-00 Narcolepsy 1 2025-10-28
INITIATE-LECIG: Intestinal levodopa + entacapone therapy (Lecigon®) to counteract dopaminergic desensitization and neuropsychiatric complica… Recruiting

2025-521048-39-00 Parkinson Disease 5 2025-10-28
Soothing Pain After ChEmotherapy: Psilocybin As INtervention (SPACE-PAIN) — a randomized controlled pilot trial Recruiting

2024-516936-93-02 chemotherapy-induced peripheral neuropathy, chronic neu 4 2025-10-28
Research into the safety of a new agent (AX-5006) in people with and without Parkinson's disease. Recruiting

2025-523254-14-00 Parkinson's disease 1 2025-10-27
A randomized, parallel-arm, double blind, placebo-controlled study to assess the efficacy of fampridine for patients with spinocerebellar at… Recruiting

2024-520413-53-00 Spinocerebellar ataxia 5 2025-10-21
C4951063: A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine Recruiting

2024-517121-10-00 Menstrual Migraine 5 2025-10-17