Nervous System Diseases

1,005 trials 421 recruiting

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Evaluation of cortisone treatment in children suffering from acute facial nerve paralysis. Ended

2024-513430-37-00 Facial Nerve Palsy (Bells Palsy) 6 2019-06-01
A multicenter study to evaluate the safety, tolerability and efficacy of XEN1101 as additional therapy to standard treatment in focal epilep… Ended

2023-508681-15-00 Adult focal (partial onset) epilepsy 4 2019-05-28
A Study of Risdiplam in Infants with Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy Ended

2023-506009-20-00 Spinal Muscular Atrophy (SMA) 4 2019-03-29
An open-label extension study evaluating long-term safety, tolerability and effectiveness of ofatumumab in subjects with RMS Ended

2023-507906-15-00 Relapsing multiple sclerosis (RMS) 5 2019-01-30
STOP-I-SEP_Disease modifying therapies withdrawal in inactive Secondary Progressive Multiple Sclerosis patients older than 50 years Ended

2024-516628-32-00 Multiple Sclerosis 5 2019-01-24
A Study to Evaluate Effectiveness and Safety of Ocrelizumab Treatment in Patients with Progressive Multiple Sclerosis Ended

2023-506429-13-00 Progressive multiple sclerosis (PMS) 5 2018-05-02
RAM-MS Ended

2024-510630-40-00 Multiple sclerosis 5 2018-02-12
A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson’s Disease (BeyoND) Ended

2024-513548-27-00 Parkinson's disease 4 2016-10-05
Adjuvant dendritic-cell immunotherapy plus temozolomide following surgery and chemoradiation in patients with newly diagnosed glioblastoma Ended

2024-515291-13-00 Glioblastoma grade IV 4 2016-04-01
A two-year, double-blind, randomized, multicenter, active controlled Core Phase study to evaluate the safety and efficacy of fingolimod admi… Ended

2023-507556-68-00 Multiple Sclerosis 5 2013-07-26
Perineural incobotulinumtoxin-A for Complex Regional Pain Syndrome - An open-label feasibility study (PINCom) Halted

2024-519832-17-00 Complex Regional Pain Syndrome 4 2026-01-07
A prospective, multicentre, randomised, double-dummy, double-blind, placebo-controlled 3-way Phase III study to investigate the efficacy and… Halted

2022-502903-31-00 Patients with ADHD (according to ICD-10 / DSM-5) 5 2025-11-05
Mechanisms of Action of Paradoxical Responses to Zolpidem: A Multimodal Study Halted

2023-507404-31-03 Patients with acquired partial/total vision impairments 4 2025-02-11
A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study, to Assess Efficacy, Safety and Immunogenicity of JNJ-6404… Halted

2023-505096-68-00 Preclinical Alzheimer’s Disease 4 2025-01-14
A Proof of Concept, Multicentre, Phase 2, Double- Blind, Randomized, Placebo-Controlled Study on the Efficacy, Safety and Tolerability of d-… Halted

2024-510968-22-00 restless leg syndrome 4 2024-03-12
A 96-Week, Prospective, Multicenter, Randomised, Double-Blind, Placebo-Controlled, Phase 3 Study to Compare Efficacy and Safety of Masitinib… Halted

2024-516672-16-00 Multiple Sclerosis 5 2024-02-02
A Phase 2b, Multicenter, Randomized, Placebo-controlled, Double-blind Study to Assess the Safety and Efficacy of AD04 in Patients with Early… Halted

2024-518523-30-00 early Alzheimer’s disease 4 2023-11-08
Evaluate the Efficacy, Safety and Tolerability of (+)-α-dihydrotetrabenazine for Treatment of Tardive Dyskinesia Halted

2024-519105-35-00 tardive dyskinesia 4 2023-08-23
Ketamine to treat patients with post-comatose disorders of consciousness Halted

2024-518433-29-00 Disorder of Consciousness, severe brain injury 4 2022-01-01
A prospective, multicenter, randomised, double-blind, placebo-controlled, parallel groups, phase 3 study to compare the efficacy and safety … Halted

2024-516671-33-00 Amyotrophic Lateral Sclerosis 5 2021-05-24
A prospective, multicenter, randomised, double-blind, placebo-controlled, parallel groups, phase 3 Trial to compare the efficacy and safety … Suspended

2024-511244-12-01 Amyotrophic Lateral Sclerosis 5
Bioequivalence study 2 to compare pharmacokinetics of Parkinson´s disease drugs in healthy volunteers Ended

2026-525449-57-00 Parkinson desease 2 2026-04-08
A study investigating the effect of curcumin on the absorption and elimination of IMU 838, a new compound that may potentially be used in th… Ended

2025-523791-24-00 Multiple sclerosis 3 2026-01-08
Open-label single dose trial to evaluate pharmacokinetics, safety, and acceptability/palatability of oveporexton in children from 6 years to… Ended

2025-522034-31-00 Narcolepsy with Cataplexy (Narcolepsy Type 1) 3 2026-01-07