Nervous System Diseases

1,005 trials 421 recruiting

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A Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ION717 in Patie… Ended

2023-503355-98-00 Prion diseases 7 2024-01-24
Comparative Study of Oral Atogepant Versus Oral Topiramate to Assess Adverse Events and Disease Activity in Adult Participants With Migraine… Ended

2022-501172-25-00 Chronic and Episodic Migraine 5 2024-01-17
A Double-blind, Randomized, Active-controlled, Parallel-group, Phase 1/3 study to Compare Efficacy, Pharmacokinetics, Pharmacodynamics and S… Ended

2022-501622-37-00 Multiple Sclerosis 5 2024-01-16
A bicentric, randomized, double blind, placebo-controlled pilot study to evaluate the efficacy and safety of satralizumab in FSHD1 Ended

2023-504507-81-00 Type 1 facioscapulohumeral muscular dystrophy 4 2024-01-15
Double-blind, randomised, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate… Ended

2024-516897-31-00 Corticobasal Syndrome (CBS) 4 2023-12-01
Metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration: a phase IIb triple-blind placeb… Ended

2023-503190-38-00 Progressive Multiple Sclerosis 4 2023-11-23
ASSESSMENT OF THE BRAIN DEPOSIT OF TAU 4R DETECTED BY BRAIN PET WITH 18F-PI2620 IN PROGRESSIVE SUPRANUCLEAR PALSY COMPARED TO CONTROLS WITHO… Ended

2023-503538-37-00 Progressive supranuclear palsy 4 2023-11-13
A double-blind, randomized, placebo-controlled trial to test the efficacy, safety and tolerability of Dimethyl Fumarate in Friedreich Ataxia… Ended

2022-503016-16-00 Friedreich's Ataxia 4 2023-11-10
A Study to Learn About the Safety of BIIB080 and Whether it Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzhe… Ended

2022-501644-15-01 Mild Cognitive Impairment due to Alzheimer's Disease Al 4 2023-09-28
CAT-Trial: CGRP monoclonal Antibody for Treatment of painful diabetic neuropathy: a double-blind, multicenter, placebo-controlled, internati… Ended

2022-500338-27-00 Painful diabetic polyneuropathy 4 2023-09-14
A Phase 2, Double-Blind, Randomized Clinical Trial to Explore the Safety, Tolerability, Efficacy, and Pharmacokinetics of PRAX-562 in Pediat… Ended

2022-502298-41-00 SCN2A and SCN8A developmental and epileptic encephalopa 4 2023-08-23
A MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY AND TOLERABILITY OF QRL-20… Ended

2022-500758-41-00 Amyotrophic lateral sclerosis 1 2023-08-15
A study to evaluate the safety, tolerability and the effects of Ixodes ricinus-Contact Phase Inhibitor (Ir-CPI) in adult patients with spont… Ended

2022-500491-53-00 Spontaneous intracerebral haemorrhage 4 2023-07-27
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB115. Ended

2023-505643-39-00 Spinal muscular atrophy 1 2023-07-17
A clinical trial to test a combination of lifestyle-based intervention with metformin in preventing dementia. Ended

2022-500438-27-01 Older adults with risk factors for dementia but dementi 4 2023-06-27
A Study to Examine the Efficacy and Safety of ZX008 in Subjects with CDKL5 Deficiency Disorder Ended

2023-506269-78-00 CDKL5 Deficiency disorder 5 2023-06-20
TRIO: A prospective randomized Trial of non-inferiority comparing RItuximab versus Ocrelizumab in relapsing-remitting multiple sclerosis. Ended

2022-501027-25-01 Multiple Sclerosis 11 2023-06-01
Noisy Rebels; Non-inferiority study of rituximab compared to ocrelizumab in relapsing MS Ended

2022-502664-21-00 multiple sclerosis 6 2023-05-01
A Trial to Evaluate the Long-term Safety and Tolerability of TAK-861 Ended

2023-508462-15-00 Narcolepsy with Cataplexy (Narcolepsy Type 1) 10 2023-04-27
A clinical study to evaluate safety and efficacy of Caribasmate Ended

2023-506616-41-00 Lennox-Gastaut syndrome (LGS) 5 2023-03-31
A clinical trial to investigate the Long-term Safety and Tolerability, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of A… Ended

2023-507052-69-00 Multifocal Motor Neuropathy 4 2023-03-29
"Open-Label Safety and Efficacy Study of Cenobamate (YKP3089) in Children with Partial-onset (Focal) Seizures " Ended

2023-506841-52-00 partial-onset (focal) seizures 5 2023-03-22
Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants Ended

2024-514004-14-00 Alzheimer’s Disease 3 2023-02-23
A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants with Prodromal and Early Manife… Ended

2023-503928-10-00 Prodromal and Early Manifest Huntington’s Disease 4 2023-02-01