Nervous System Diseases

1,005 trials 421 recruiting

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A Randomized, Placebo-Controlled, Double-Blind, Single Dose, Phase 1 Study to Explore the PK/PD Relationship of QRL-101 in People Living Wit… Ended

2024-515021-29-00 Amyotrophic lateral sclerosis (ALS) 3 2024-11-11
Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Idiopathic Generalized Epilepsy with Generalized Tonic-clonic Seizures – SHIN… Ended

2023-508812-45-00 Idiopathic Generalized Epilepsy with Generalized Tonic- 10 2024-11-11
An open label, randomized, crossover, two-period, two-sequence, multiple dose study to assess the relative bioavailability of Rotigotine 4.5… Ended

2024-515841-41-00 Not applicable (submitted trial is a bioavailability st 2 2024-11-04
The headache-inducing effects of sildenafil in men and women with episodic migraine without aura. Ended

2024-512014-17-02 Migraine without aura 9 2024-11-01
A single-center study to assess the effect of lamivudine (3TC) on cognitive impairment (alterations in thinking, learning, memory...) by the… Ended

2024-514330-20-00 Mild Cognitive impairment due to Alzheimer Disease 4 2024-10-25
A safety and efficacy study of ARGX-119 in adult patients with Amyotrophic Lateral Sclerosis (ALS) (reALiSe) Ended

2024-511318-19-00 Amyotrophic Lateral Sclerosis (ALS) 4 2024-10-23
A Study to Evaluate the Efficacy and Safety of TAK-861 for the Treatment of Narcolepsy with Cataplexy Ended

2024-511998-30-00 Narcolepsy with Cataplexy (Narcolepsy Type 1) 5 2024-10-18
A Phase 1 Open-Label Mass Balance clinical trial to Investigate the Absorption, Metabolism, and Excretion of Single Oral Administration of [… Ended

2024-515556-20-00 Healthy participant 3 2024-10-07
A study to determine if BHV-2100 and BHV-7000 are effective, safe, and tolerable as a pain medication in healthy male participants Ended

2024-512187-57-00 Pain 3 2024-10-07
Open label, single-center, cross-over randomized, relative bioavailability study comparing a new pitolisant hydrochloride tablet formulation… Ended

2024-513383-26-00 Narcolepsy 3 2024-10-01
An open label, randomized, crossover, two-period, two-sequence, single dose study to assess the relative bioavailability of Rotigotine 4.5 m… Ended

2024-515840-21-00 Not applicable (submitted trial is a bioavailability st 2 2024-09-30
A Continuation Study of Latozinemab in Participants with Neurodegenerative Disease Ended

2023-506805-20-01 Neurodegenerative Diseases 5 2024-09-25
A single-centre, open-label, phase I trial evaluating the pharmacokinetics of single ascending oral doses of IRL757 in healthy elderly volun… Ended

2024-515124-36-00 Apathy in neurodegenerative disorders 3 2024-09-24
A clinical study of MK-5661 and placebo in healthy people (MK-5661-006) Ended

2024-514980-25-00 Pain 3 2024-09-18
Phase Ib Safety, Tolerability and Pharmacokinetic Study of Subcutaneously Administered HER-096 in Healthy Volunteer Subjects and Patients wi… Ended

2024-512532-30-00 Parkinson’s Disease 3 2024-09-18
A study to learn how much minzasolmin gets into the body when taken in different ways and how safe it is in healthy adults Ended

2024-511301-31-00 Healthy Participants 3 2024-09-06
A study on the effects of a new drug on the sensitivity of the nerves in healthy volunteers Ended

2024-515390-99-00 Hyperexcitability nerve disorder 3 2024-09-06
A Study to Evaluate the Efficacy and Safety of TAK-861 for the Treatment of Narcolepsy with Cataplexy Ended

2023-508465-32-00 Narcolepsy with Cataplexy (Narcolepsy Type 1) 5 2024-09-03
Safety and Efficacy of NMD670 in Adult Patients with Type 1 and Type 2 Charcot-Marie-Tooth Disease Ended

2023-507892-23-00 Charcot-Marie-Tooth Disease Type 1 and Type 2 4 2024-08-30
A Phase 1, Open-Label, Multiple-Part Trial to Evaluate the Drug-Drug Interaction Potential of PRAX-628 in Healthy Participants Ended

2024-514426-23-01 Epilepsy 3 2024-08-28
Safety Study to Compare the Gastrointestinal Tolerability of Oral Tegomil Fumarate and Dimethyl Fumarate (Tecfidera®) in Healthy Volunteers. Ended

2023-508439-30-00 Multiple Sclerosis 3 2024-08-21
A dose-finding trial with LU AG90222 in adults with migraine who have not been helped by prior preventative treatments. Ended

2023-508821-28-00 Migraine 4 2024-08-14
Repeated corticosteroid injections around the Greater Occipital Nerve (GON) as prophylactic treatment in chronic cluster headache Ended

2024-514311-10-00 Cluster headache 5 2024-08-10
OXYTAHANE - Oxygen therapy: Acute Treatment for paroxysmal dystonic or plegic attacks in alternating hemiplegia of childhood Ended

2023-508413-16-00 Alternating Hemiplegia of Childhood 4 2024-08-07