Therapeutic Confirmatory (Phase III)

3,259 trials 1,319 recruiting

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A long term Investigation of the Safety and Efficacy of Odevixibat in Patients with Alagille syndrome Ended

2023-509028-17-00 Alagille Syndrome 2022-01-06
A Phase 3 Study Comparing Pirtobrutinib (LOXO-305) to Bendamustine plus Rituximab in Untreated Patients with CLL/SLL Ended

2024-511599-33-00 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 2021-12-22
DESTINY-Breast11 will compare trastuzumab deruxtecan (T-DXd) alone or in sequence with other medications, known as THP, with standard of car… Ended

2023-505210-18-00 Early stage HER2-positive breast cancer (T stage >= T3, 2021-12-17
A study to investigate the efficacy and safety of trastuzumab deruxtecan as the first treatment option for locally advanced/metastatic Non-S… Ended

2023-503674-20-00 Unresectable, locally advanced, or metastatic Non-Small 2021-12-17
This is a multicenter, randomized, Phase 3 study with vimseltinib or placebo in patients with Tenosynovial Giant Cell Tumor, consisting of 2… Ended

2024-513624-42-00 Tenosynovial Giant Cell Tumor 2021-12-16
A research study to compare different doses of a new investigational medicinal product for treatment of certain patients with Duchenne muscu… Ended

2024-511492-15-00 Duchenne Muscular Dystrophy 2021-12-09
Efficacy and Safety of Selumetinib in Adults with NF1 who have Symptomatic, Inoperable Plexiform Neurofibromas. Ended

2023-507336-20-00 Neurofibromatosis Type 1 (NF1) with Symptomatic, Inoper 2021-12-08
Blood thinners after transcatheter implantation of a new heart valve in patients with aortic stenosis Ended

2023-510211-20-00 Aortic stenosis 2021-12-07
Shortened vs standard chemotherapy combined with immunotherapy for the initial treatment of patients with high tumor burden Follicular Lymph… Ended

2024-511636-27-00 Follicular Lymphoma 2021-12-01
A Phase 3, Multicenter, Open-label, Basket, Long-term Extension Study of Ustekinumab in Pediatric Clinical Study Participants (2 to <18 Year… Ended

2022-501067-40-00 Moderately to Severely Active Ulcerative Colitis 2021-11-30
A Study to Evaluate the Efficacy and Safety of BIIB059 (Litifilimab) in Adult Participants With Active Systemic Lupus Erythematosus Receivin… Ended

2023-505695-30-00 systemic lupus erythematosus 2021-11-30
A Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRA… Ended

2023-506241-30-00 Advanced Colorectal Cancer with KRAS G12C Mutation 2021-11-30
A clinical study to assess the efficacy of alpelisib plus fulvestrant in participants with HR-positive, HER2-negative, advanced breast cance… Ended

2023-509133-39-00 Hormone receptor positive, HER2-negative advanced breas 2021-11-29
A clinical study to assess the efficacy and safety of lanifibranor followed by an active treatment extension in adult patients with non-cirr… Ended

2023-508248-23-00 Non-alcoholic steatohepatitis (NASH) 2021-11-26
A research study to find out whether a medicine called inclisiran helps to prevent cardiovascular death, heart attacks or strokes in people … Ended

2024-510735-21-00 Atherosclerotic cardiovascular disease (ASCVD) 2021-11-26
Endoscopic evidence of maintenance of healing with oral NEXIUM in patients 1 to 11 years old with erosive esophagitis. Ended

2023-505454-18-00 Erosive Esophagitis 2021-11-24
Study to Evaluate the Safety and Efficacy of Crinecerfont in Pediatric Patients With Classic Congenital Adrenal Hyperplasia Ended

2023-509170-33-00 Classic Congenital Adrenal Hyperplasia (CAH) 2021-11-23
A Study to Evaluate Efficacy and Safety of Mosunetuzumab in Combination with Lenalidomide in Comparison to Rituximab in Combination with Len… Ended

2023-505807-21-00 Relapsed/refractory follicular lymphoma 2021-11-16
A Clinical Study of Amivantamab and Lazertinib in Combination with Platinum-Based Chemotherapy Compared with Platinum-Based Chemotherapy in … Ended

2023-506518-33-00 Locally Advanced or Metastatic Non-Small Cell Lung Canc 2021-11-10
Long-term safety and tolerability of iptacopan in patients with Paroxysmal Nocturnal Hemoglobinuria Ended

2023-509843-28-00 Paroxysmal Nocturnal Hemoglobinuria (PNH) 2021-11-10
An International, Randomized, Double-Blind, Phase III Study of Fuzuloparib Combined with Abiraterone Acetate and Prednisone (AA-P) versus Pl… Ended

2023-509396-16-00 Metastatic Castration-Resistant Prostate Cancer 2021-11-08
Efficacy of Abatacept vs Adalimumab in Early, Autoantibody positive Rheumatoid Arthritis (RA) and who did not respond well to methotrexate. Ended

2023-506450-20-00 Rheumatoid Arthritis 2021-11-05
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Patients with Systemic Lupus Erythematosus (ALLEGORY) Ended

2023-504774-38-00 Systemic Lupus Erythematosus (SLE) 2021-11-04
Efficacy and Safety of Deucravacitinib Compared with Placebo in Participants with Active Psoriatic Arthritis (PsA) who are Naïve to Biologic… Ended

2023-506257-37-00 Active Psoriatic Arthritis 2021-10-29