Phase I/II – First Administration

453 trials 190 recruiting

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A 2-Part, Randomized, Double-Blind, Placebo-Controlled Study in Participants with Duchenne Muscular Dystrophy Amenable to Exon 45 Skipping t… Recruiting

2024-517499-39-00 Duchenne Muscular Dystrophy 2025-07-16
Master protocol of TCR-modified T cell therapy targeting HLA-restricted KRAS antigen administered in adult patients with metastatic or local… Recruiting

2024-513900-32-00 Pancreatic Ductal Adenocarcinoma 2025-07-03
RR001, a cell-based gene therapy administered in combination with chemotherapy for the treatment of patients with locally advanced pancreati… Recruiting

2024-516019-26-00 Ductal adenocarcinoma of pancreas 2025-06-25
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma (ADCElerate 1) Recruiting

2024-516900-41-00 Soft Tissue Sarcoma 2025-06-24
A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy Recruiting

2024-514501-57-00 Duchenne muscular dystrophy 2025-06-20
BreAK CRC (001) trial Recruiting

2024-512011-45-00 Unresectable locally advanced or metastatic colorectal 2025-06-17
A Trial to Learn if REGV131-LNP1265 is Safe and Works to Help the Body Make Clotting Factor in Adult Patients with Hemophilia B Recruiting

2023-507260-40-00 Hemophilia B 2025-06-16
A clinical study to assess the safety and efficacy of oral ART0380 as a single agent or in combination in solid tumors Recruiting

2024-511534-12-00 Advanced or Metastatic Solid Tumours 2025-06-10
A Study to Assess a New Medicine Called IPN01195 When Administered Alone in Adults With Advanced Solid Tumours Recruiting

2024-519184-18-00 Advanced Solid Tumour 2025-05-30
Randomized, controlled, multicenter Phase I/II study comparing the safety and immunogenicity of a booster dose of an intranasal COVID-19 vac… Recruiting

2024-510589-17-00 Healthy volunteers 2025-05-09
A Study to Investigate ALE.P02 as Monotherapy or in Combination with Pembrolizumab in Adult Patients with Selected CLDN1+ Solid Tumors Recruiting

2024-515459-39-00 Advanced or Metastatic Squamous Solid Tumors 2025-05-08
A Phase 1/2, Open-Label Study to Evaluate the Safety and Efficacy of Autologous CD19-specific Chimeric Antigen Receptor T cells (CABA-201) i… Recruiting

2023-507613-10-01 Active Systemic Lupus Erythematosus;Systemic lupus eryt 2025-03-31
First -in-Human Study of DS-3939a in Subjects with Advanced Solid Tumors Recruiting

2023-507937-14-00 Metastatic Solid Tumor 2025-03-25
Dose escalation of allogeneic Adipose derived Stroma/stem Cells for the treatment of Crohn’s fistula Recruiting

2024-511821-75-00 Crohn’s fistula 2025-03-13
Eight-Treg study: a phase I dose escalation trial of adoptive immunotherapy with autologous ex vivo expanded regulatory CD8+ T cells in livi… Recruiting

2024-513771-40-01 chronic renal failure requiring kidney transplantation 2025-03-03
A clinical trial to learn about the safety and effects of VERT-002, a new anticancer drug for the treatment of patients with advanced solid … Recruiting

2024-512760-64-00 locally advanced or metastatic solid tumors with MET al 2025-02-26
Study of ARO-DUX4 in Adult Patients With Facioscapulohumeral Muscular Dystrophy Type 1 Recruiting

2023-509748-89-00 Facioscapulohumeral muscular dystrophy (FSHD) 2025-02-19
Phase I/II study of anti-GD2 Chimeric Antigen Receptor-Expressing T cells in pediatric patients affected by High Risk and/or relapsed/refrac… Recruiting

2024-520436-15-00 High Risk and/or relapsed/refractory Neuroblastoma and 2025-02-18
A Phase 1/2 Dose-Exploration and Dose-Expansion Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients with Alpha-1 Antitry… Recruiting

2023-509256-34-00 Alpha-1 Antitrypsin Deficiency (AATD)-Associated Lung D 2025-02-06
Safety and tolerability of TOP-N53 applied on digital ulcers in patients with systemic sclerosis Recruiting

2024-511861-12-00 Digital ulcers in systemic sclerosis 2025-02-04
A trial in patients suffering from a specific form of an eye disorder called retinitis pigmentosa Recruiting

2023-504383-42-00 Retinitis Pigmentosa (due to CNGA1 mutation) 2025-02-02
A Phase 1/2 Study of EG-70 as an Intravesical Administration to Patients With BCG Unresponsive Non-Muscle Invasive Bladder Cancer (NMIBC) an… Recruiting

2024-512900-20-00 Non-muscle invasive bladder cancer (NMIBC) 2025-01-30
A first-in-human, dose escalation and dose expansion study of SAR445877 in adult participants with advanced solid tumors Recruiting

2023-507141-28-00 Solid tumor 2025-01-29
Study of ORIC-114 in Patients with Advanced Solid Tumors Harboring an EGFR or HER2 Alteration Recruiting

2024-512264-66-00 Solid Tumors 2025-01-29