Phase I/II – First Administration

454 trials 191 recruiting

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A trial to learn how safe AZD4512 is and how it works in the bodies of people with B-cell acute lymphoblastic leukemia (B-ALL) Recruiting

2025-522372-93-00 B-cell acute lymphoblastic leukemia (B-ALL) 2026-01-13
A trial to learn how safe AZD4360 is, how well it works, and how it moves throughout the body over time in adults with advanced solid tumors Recruiting

2024-518281-27-00 Gastric Cancer, Gastroesophageal Junction Cancer, Bilia 2026-01-09
A trial to learn how safe AZD4512 is with and without other cancer drugs and how it works in the bodies of people with B-cell non-Hodgkin ly… Recruiting

2025-522371-29-00 Non-Hodgkin lymphoma (NHL) 2025-12-19
A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants with Advanced Solid Tumors Recruiting

2025-522203-23-00 Advanced Solid Tumors 2025-12-18
A Study to Test the Safety and Effects of a New Cancer Drug (TUB-030) in Patients with Advanced Solid Tumors Recruiting

2025-522517-35-00 Patients with advanced/metastatic tumors with head and 2025-12-16
QUADvance: Advancing Allogeneic Quad-CAR01-T Therapy in Hard-to-Treat B-Cell Cancers Recruiting

2025-521735-36-00 Relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B- 2025-12-15
A study to investigate the safety and efficacy of ONA-255 in participants with advanced cancer Recruiting

2025-522233-62-00 Advanced cancer; breast cancer; metastatic gastric / ga 2025-12-12
A Phase 1/2 Study of BMS-986482 Alone or Combination Therapy in Participants with Advanced Solid Tumors Recruiting

2024-516602-28-00 Advanced Solid Tumors 2025-11-21
GAIN-CTNNB1: A Phase I/II open-label trial to evaluate the safety, tolerability, and preliminary efficacy of a single intracerebroventricula… Recruiting

2025-522719-40-00 CTNNB1 syndrome 2025-11-21
A first-in-human study to learn how safe BAY 3713372 is and how it works in participants with MTAP-deleted solid tumors Recruiting

2025-520623-24-00 MTAP-deleted Solid Tumors 2025-11-19
A Phase Ib/II first-in-human, multicentre, open-label, multiple ascending dose study of S230815 in paediatric participants with KCNT1-relate… Recruiting

2024-513332-17-00 KCNT1-related Developmental and Epileptic Encephalopath 2025-11-19
A First-In-Human, phase I/IIa, open-label trial assessing safety, tolerability, and feasibility of repeated administrations of a novel autol… Recruiting

2025-521227-70-00 Patients with locally advanced or metastatic prostate c 2025-11-13
Trial of THEO-260 in Ovarian Cancer Patients (OCTOPOD) Recruiting

2024-511236-27-00 High grade serous or endometroid ovarian cancer 2025-11-12
Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and Other Advanced Solid Tumors Recruiting

2024-517281-42-00 Advanced solid tumors 2025-11-12
Monocentric, open-label, single-arm, phase I/II clinical trial to evaluate the use of the ONCOGREEN galenic formulation consisting of indocy… Recruiting

2025-521273-14-00 Solid neoplasms of the digestive system (primary and/or 2025-11-10
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Study of Investigational Agents With or Without Pembrolizumab in Participants with PD-1… Recruiting

2023-506384-34-00 Locally advanced or metastatic urothelial carcinoma 2025-11-05
Phase 1/2a study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of SQY51 in Paediatric and Adult Patients with a Genetically… Recruiting

2022-500703-49-01 Duchenne muscular dystrophy 2025-11-05
A phase Ib/II first-in-human imaging study of anti-GD2-800CW in patients with neuroblastoma. Recruiting

2023-507596-22-00 Neuroblastoma 2025-11-05
Effect of TRI-001 in patients with chronic limb threatening ischemia Recruiting

2024-517765-16-00 Patients with Chronic Limb Threatening Ischemia (CLTI) 2025-11-01
Phase I/IIa study to test the safety and efficacy of MSC from umbilical cord tissue (UC-MSC) for the treatment of cartilage damage in the kn… Recruiting

2024-517684-23-00 Cartilage defect of the knee joint 2025-10-23
A Phase 1/2 Study to Assess AMG 732 in Healthy Subjects and Subjects with Thyroid Eye Disease Recruiting

2024-514110-12-00 Thyroid Eye Disease 2025-10-22
A Phase 1/2, Multicenter, Open Label, Dose Escalation and Dose Expansion Study of JK06, a 5T4 Antibody Drug Conjugate, in Patients with Unre… Recruiting

2024-512421-92-00 Unresectable, Locally Advanced or Metastatic Cancer 2025-10-14
Intracochlear application of (Extracellular Vesicle-enriched Secretome Fraction; VSF1.01) for the Reduction of Cochlear Implant Surgery Rela… Recruiting

2024-512498-29-00 hearing loss 2025-09-24
Trial of an investigational drug after the rejection of an allogeneic transplant. Recruiting

2022-503063-15-00 Multiple myeloma. 2025-09-22