Phase I/II – First Administration

453 trials 190 recruiting

Filter these 453 trials by condition, country, sponsor and more.

Open in Search →

A first-in-human clinical trial using a gene therapy with patient’s own stem cells to treat early type 1 diabetes Recruiting

2025-521304-21-00 Type 1 diabetes 2026-03-13
Study of GS-4321 in Healthy Participants and Participants With Chronic Hepatitis Delta Virus. Recruiting

2025-522729-36-00 Chronic Hepatitis Delta. 2026-03-11
A Phase 1/2 study of ALXN2350 in adult participants with BAG3-associated dilated cardiomyopathy Recruiting

2024-519674-40-00 BAG3 Mutation Associated Dilated Cardiomyopathy 2026-02-05
A Phase 1/2a Study of UCART20x22 in B-Cell Non-Hodgkin Lymphoma [NatHaLi-01] Recruiting

2022-501607-27-00 Relapsed or refractory B-cell Non-Hodgkin lymphoma 2026-01-06
A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors Recruiting

2025-521672-60-00 Metastatic or locally advanced SST2-positive neuroendoc 2025-12-19
A trial to learn how safe AZD3632 is, how well it works, and how it moves throughout the body over time in adults with acute leukemia and my… Recruiting

2025-521299-76-00 Relapsed or refractory acute leukaemia or Myelodysplast 2025-12-18
A Phase 1-2, Double-Blind, MAD Study of ION440 in MDS Recruiting

2023-507192-22-00 Methyl CpG binding protein 2 (MECP2) Duplication Syndro 2025-10-24
Evaluation of long-term safety in parkinsonian patients with intracerebroventricular administration of A-dopamine (anaerobic dopamine) - (DI… Recruiting

2025-522261-30-00 Parkinson disease 2025-10-01
Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 Recruiting

2024-518144-20-00 Primary Hyperoxaluria Type 1 (PH1) 2025-09-03
BOLD-100 in Combination with FOLFOX for the Treatment of Advanced Solid Tumours Recruiting

2024-517500-11-00 Colorectal Cancer 2025-07-15
A Phase 1/2a, First-in-human Study to Evaluate BMS-986470 in Healthy Volunteers and Participants with Sickle Cell Disease Recruiting

2023-510283-12-00 Sickle Cell Disease 2025-06-12
First trial in humans testing the safety and efficacy of IMGN151 in women with recurrent gynaecological cancers Recruiting

2023-506842-22-00 Recurrent endometrial cancer, recurrent epithelial ovar 2025-05-19
Phase I/II ex vivo gene therapy clinical trial for RDEB using autologous skin equivalent grafts genetically corrected with a COL7A1-encoding… Recruiting

2024-518368-10-00 Recessive dystrophic epidermolysis bullosa (RDEB) 2025-01-29
Clinical trial of MDNA11 (investigational drug) administered alone or in combination with pembrolizumab (immune checkpoint inhibitor) in Pat… Recruiting

2023-507536-21-00 Advanced Solid Tumors 2024-10-04
Kidney cancer Recruiting

2023-505605-16-00 Metastatic Clear Cell Renal Cell Carcinoma (ccRCC) or p 2024-04-24
Study to assess the safety and efficacy of the SpectraCure P18 System Recruiting

2022-502285-24-00 Recurrent prostate cancer 2024-03-01
Safety and effect of mesenchymal derived Extracellular Vesicles in the prevention of Bronchopulmonary Dysplasia in extremely preterm newborn… Recruiting

2022-500293-34-01 Bronchopulmonary Dysplasia 2023-12-28
A study to learn how mRNA 4359 works in the body and how safe it is in participants with advanced solid tumor cancer when administered alone… Recruiting

2023-504506-11-00 Advanced Solid Tumors 2023-10-09
A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given with Either Cemiplimab, or Cemiplimab + Fianlimab, … Recruiting

2022-501904-83-00 Ovarian Cancer 2023-09-11
A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of … Recruiting

2023-504254-35-00 Unresectable locally advanced or metastatic solid tumor 2023-06-20
First in human study of BAY2927088 in participants who have advanced non-small cell lung cancer (NSCLC) with mutations in the genes of epide… Recruiting

2023-503795-24-00 Avanced Non-Small Cell Lung Cancer 2022-09-16
A Phase 1/2/3 Study of UX701 Gene Therapy in Adults with Wilson Disease”. Recruiting

2022-502873-40-00 Wilson disease 2022-06-13
Phase 1/2 dose-escalation study to evaluate the safety, tolerability, and efficacy of a single intravenous infusion of SPK-3006 in adults wi… Recruiting

2023-509303-32-00 Pompe Disease (also known as glycogen storage disease t 2021-10-19
A Phase 1/2 First in Human Study of the Menin-MLL (KMT2A) Inhibitor KO-539 in Patients with Relapsed or Refractory Acute Myeloid Leukemia Recruiting

2023-510509-17-00 Relapsed and/or refractory Acute Myeloid Leukemia 2020-06-17