Phase I/II – First Administration

454 trials 191 recruiting

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Phase 1/2 dose-escalation study to evaluate the safety, tolerability, and efficacy of a single intravenous infusion of SPK-3006 in adults wi… Recruiting

2023-509303-32-00 Pompe Disease (also known as glycogen storage disease t 2021-10-19
A Phase 1/2 First in Human Study of the Menin-MLL (KMT2A) Inhibitor KO-539 in Patients with Relapsed or Refractory Acute Myeloid Leukemia Recruiting

2023-510509-17-00 Relapsed and/or refractory Acute Myeloid Leukemia 2020-06-17
A prospective multicentre single-arm study in adults to evaluate the safety and preliminary efficacy of the autologous 3D osteogenic implant… Recruiting

2024-517762-42-01 recalcitrant lower limb nonunion 2018-08-02
A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy) Recruiting

2024-512358-78-00 Solid Tumors 2015-01-20
A Study of S241656 in Patients With KRAS, BRAF and Other Selected RAS/MAPK Mutation-Positive Malignancies Recruiting

2025-523474-16-00 Malignancies with Documented KRAS, BRAF and Other Selec 2026-06-09
LUMC-BOB1-B7-TCR.1 in relapsed and refractory B-cell malignancies Recruiting

2024-515900-38-00 B-cell Acute Lymphoblastic Leukemia 2026-06-05
A phase I/II open label study to assess safety, feasibility and efficacy of ex vivo expanded, autologous haematopoietic stem and progenitor … Recruiting

2024-518972-30-00 Autosomal recessive osteopetrosis caused by mutations i 2026-06-04
Phase 1/2A Study of OTP-01, a Dual Paratopic PD-1/VEGFR2 Antibody, in Patients with Advanced Solid Tumors Recruiting

2025-524111-37-00 advanced solid tumors 2026-04-28
Study of ART6043 in Advanced/Metastatic Solid Tumors Patients Recruiting

2023-509220-17-00 Metastatic solid tumors 2026-04-10
The STELLAR trial: Fluorescence-guided surgery in laryngeal- and hypopharyngeal cancer: a feasibility trial Recruiting

2024-519750-36-00 Squamous cell carcinoma of the larynx and hypopharynx 2026-03-31
An early phase trial of RPTR-1-201 in Advanced Solid Tumors Recruiting

2025-524010-28-00 Advanced Solid Tumor 2026-03-20
(Title in lay language): A trial to learn how safe AZD0516 is and how well it works with and without other cancer treatments in adults with … Recruiting

2024-520026-11-00 Metastatic Prostate Cancer 2026-03-19
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known t… Recruiting

2025-522613-26-00 Advanced Solid Cancers 2026-03-13
A Phase 1 Study of Fentanyl Vaccine Recruiting

2025-524277-16-00 Opioid induced respiratory depression 2026-02-26
A Phase 1/2 Open Label Cohort Comparative Study Evaluating the Efficacy and the safety of Gene Therapy of the Sickle Cell Disease by Transpl… Recruiting

2025-521257-17-00 SCD severe patients 2026-02-25
A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adult… Recruiting

2025-522184-15-00 Advanced Solid Tumor, Metastatic Solid Tumor 2026-02-18
A Clinical Trial to learn about the effects of TLN-372 when given Alone and in Combination with Other Anti-Tumor Agents in people with Advan… Recruiting

2025-523086-22-00 Locally advanced or metastatic solid tumors 2026-02-18
A Phase 1/2 clinical trial of DT-7012 as monotherapy and in combination with an immune checkpoint inhibitor in participants with selected ad… Recruiting

2025-523758-15-00 Cancer 2026-02-11
A study to assess the safety, tolerability, pharmacokinetic, pharmacodynamic, immunogenicity and antitumour activity of IPN60300 in adults w… Recruiting

2025-522139-33-00 Advanced or metastatic solid tumours 2026-02-10
A first-in-human study to determine a safe dose of the drug TD001 to treat patients with metastatic prostate cancer that expresses the PSMA … Recruiting

2025-523273-41-00 Metastatic castration-resistant prostate cancer 2026-01-30
A Phase 1-2 Master Protocol to Study Intravenous ATTR-01 in Adult Participants with Select Epithelial Solid Tumours Under Multiple Sub-proto… Recruiting

2024-516722-59-00 Select Epithelial Solid Tumours 2026-01-23
A Study to test ALE.P03 in Adult Patients with Selected Advanced or Metastatic CLDN1+ Solid Tumors Recruiting

2025-521441-24-00 Advanced or Metastatic Solid Tumors 2026-01-19
A Phase 1/2 First-Time-in-Human study of GSK5458514 administered alone or in combination with other anti-cancer agents in participants with … Recruiting

2025-521581-10-00 Neoplasms, Prostate 2026-01-16
A Clinical study of MK-4716 in people with certain solid tumors (MK-4716-001) Recruiting

2025-522495-84-00 Cancer – Solid Tumors : 1L NSCLC and all other advanced 2026-01-14