Nervous System Diseases

1,005 trials 421 recruiting

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A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Rimegepant in Migraine Prevention in Ch… Recruiting

2024-512382-13-00 Migraine (with or without aura) 5 2022-10-04
An extension study to learn if Staccato Alprazolam is safe when treating long seizures in children ≥12 years of age and adults Recruiting

2023-508868-30-00 Treatment of stereotypical prolonged seizure 5 2022-09-26
A multicenter, double-blind, randomized study to evaluate the effects of tasimelteon vs. placebo in participants with Delayed Sleep-Wake Pha… Recruiting

2024-516962-13-00 Delayed Sleep-Wake Phase Disorder (DSWPD) 5 2022-09-23
A prospective, single-center phase I pilot study to assess the tissue activity of multidrug resistance-associated protein 1 with positron em… Recruiting

2024-517851-11-00 Investigation in healthy volunteers and Alzheimer's dis 1 2022-09-05
An outpatient study to learn if Staccato Alprazolam is safe and effective when treating long seizures in children ≥12 years of age and adult… Recruiting

2024-510950-29-00 Stereotypical prolonged seizure 5 2022-07-21
Neuromyelitis Optica Spectrum Disorder Inebilizumab Study in Children and Adolescents Recruiting

2023-510007-22-00 Neuromyelitis optica spectrum disorder (NMOSD; also kno 4 2022-07-20
A First-in-Human Study to Evaluate the Safety and Tolerability of ALN-APP in Patients with EOAD Recruiting

2023-508363-79-00 Early-onset Alzheimer's disease (EOAD) 1 2022-06-29
Effects of ozanimod on myelin dynamics and neurodegeneration in patients with relapsingremitting multiple sclerosis: correlation with diseas… Recruiting

2024-513960-24-00 Multiple sclerosis patients in relapse and remission fo 6 2022-06-22
A randomised, double blind clinical trial investigating the safety and tolerability of multiple increasing doses of EDV2209 compared to plac… Recruiting

2024-514590-22-00 Subarachnoid haemorrhage – SAH 7 2022-03-10
Exploration of the pathophysiology of cluster headache (AVF) in PET-MRI using [18F]F13640 Recruiting

2024-513873-36-00 Nervous System Diseases 4 2022-02-28
Effect of siponimod on relevant imaging and immunological hallmarks of progressive multiple sclerosis Recruiting

2024-518374-13-00 Active progressive multiple sclerosis course after an i 6 2022-02-28
Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-101 in Participants with Myotonic Dystrophy Type 1 Recruiting

2023-510353-42-00 Myotonic Dystrophy Type 1 7 2022-02-21
CHOLINE-2 - Donepezil Versus Non-drug Treatment in Alzheimer's Disease Recruiting

2024-515038-34-00 Interest of adding donepezil to the non-medicinal care 6 2022-02-10
Open- label study in children and adolescents with migraine: Acute Treatment Recruiting

2024-512744-32-00 Acute Migraine (with or without aura) 5 2022-02-01
A multicentre study evaluating the safety of reperfusion thrombolytic therapy with intravenous recombinant tissue plasminogen activator (rtP… Recruiting

2024-518509-17-00 Acute ischemic stroke 4 2022-01-10
Riluzole in spinocerebellar ataxia type 7 Recruiting

2024-518962-29-00 Spinocerebellar ataxia type 7 (SCA7) 4 2021-12-07
Intrathecal application of PD-1 antibody in metastatic solid tumors with leptomeningeal disease Recruiting

2024-514068-14-00 leptomeningeal disease 9 2021-10-12
A Study to Learn About the Efficacy and Safety of Rimegepant for the Acute Treatment of Migraine in Children and Adolescents. Recruiting

2024-512743-23-00 Acute Migraine (with or without aura) 5 2021-08-31
A Study to Investigate the Safety, Tolerability, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of RO7121932 following Intravenous a… Recruiting

2023-509357-31-00 Multiple Sclerosis (MS) 1 2021-06-01
Comparison of the efficacy and safety of rapamycin versus vigabatrin in the prevention of Tuberous Sclerosis Complex symptoms in infants in … Recruiting

2024-513068-25-00 Tuberous Sclerosis Complex, Epilepsy, Tumors associated 10 2021-05-20
Partial oral antibiotic treatment for bacterial brain abscess: An open-label randomised non-inferiority trial (ORAL) Recruiting

2023-505483-11-00 Brain abscess 6 2021-05-02
A study investigating single injection of new botulinum toxin to determine safety and efficacy for treating spasticity in the upper limb Recruiting

2023-507202-14-00 Upper limb spasticity after stroke or traumatic brain i 7 2021-04-29
A phase IIa multicentre randomized controlled double blind clinical trial to demonstrate clinical efficacy on cognitive, neuropsychiatric an… Recruiting

2024-510720-38-00 Dementia with Lewy Bodies 4 2021-01-12
Improvement of functional outcome for patients with newly diagnosed grade 2 or 3 glioma with co-deletion of 1p/19q - IMPROVE CODEL: the NOA-… Recruiting

2024-510616-73-00 newly diagnosed WHO grade 2 or 3 glioma 5 2020-12-16