Hemic and Lymphatic Diseases

593 trials 238 recruiting

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A Study to Assess Safety, Effectiveness, Pharmacokinetics, and Pharmacodynamics of RO7112689 in Healthy Volunteers and Patients with Paroxys… Ended

2023-506287-14-00 Paroxysmal nocturnal hemoglobinuria (PNH) 7 2017-04-21
Clinical trial with Ibrutinib and Venetoclax for patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Ended

2024-514686-19-00 Relapsed or Refractory Chronic Lymphocytic Leukemia 4 2017-03-10
A Clinical trial to compare Acalabrutinib (ACP-196) versus investigator's choice standard treatment with Bendamustine/Rituximab or Idelalisi… Ended

2023-509359-15-00 Relapsed or Refractory Chronic Lymphocytic Leukemia 5 2017-03-08
A clinical trial to evaluate the safety and effectiveness of a combination of either AG-12or AG-221 tablets with azacitidine injections in p… Ended

2024-511722-31-00 Acute Myeloid Leukemia (AML) 9 2016-11-29
PIO2STOP_Combination study of Pioglitazone and Tyrosine Kinase Inhibitors (TKIs) in Chronic Myeloid Leukemia patients after failure of a TKI… Ended

2024-515460-31-00 CHRONIC PHASE CHRONIC MYELOGENOUS LEUKAEMIA 4 2016-11-07
Sustained treatment-free period in the course of a disease when symptoms become less severe in BCR-ABL+ chronic myeloid leukemia: a prospect… Ended

2023-510434-83-00 Chronic Myeloid Leukemia (CML) in Chronic Phase (CP) 6 2016-10-17
A Phase Ib-II Study of tazemetostat (EPZ-6438) in newly diagnosed Diffuse Large B Cell Lymphoma (DLBCL) or high risk Follicular Lymphoma (FL… Ended

2024-515846-18-00 Newly diagnosed Diffuse Large B Cell Lymphoma 7 2016-09-19
A prospective phase II study to assess the minimal residual disease after ixazomib plus lenalidomide plus dexamethasone (IRd) treatment for … Ended

2024-517321-99-00 Myeloma multiplex 4 2016-08-01
A Phase 1 study to test the safety of an oral investigational drug (either AG-120 or AG-221) in combination with standard chemotherapeutic … Ended

2024-511380-29-00 Newly Diagnosed Acute Myeloid Leukemia with an IDH1 and 3 2015-12-16
A trial to learn how well osimertinib (AZD9291) works to prevent cancer from coming back after surgery and how safe it is compared to the pl… Ended

2023-506524-82-00 Stage IB-IIIA non-small cell lung carcinoma, with a cen 5 2015-10-21
Ruxolitinib versus Best Available Therapy in patients with high-risk polycythemia vera or high-risk essential thrombocythemia – The Ruxo-BEA… Ended

2024-515619-23-00 essential thrombocythemia 4 2015-06-29
HOVON 127 BL / SAKK 37/16: Phase III study comparing 2 treatments (R-CODOX-M/R-IVAC versus DA-EPOCH-R) in patients with Burkitt lymphoma Ended

2023-503423-25-00 Burkitt lymphoma 5 2014-06-19
A randomized phase III multicenter trial assessing efficacy and toxicity of a combination of Rituximab and Lenalidomide (R2) vs Rituximab al… Ended

2024-511640-11-00 Follicular lymphoma 5 2014-05-15
Long-term study evaluating the effect of givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms Ended

2024-512413-40-00 Chronic myeloproliferative neoplasm 4 2013-03-08
Long-Term Follow-up of Subjects With Transfusion-Dependant β-Thalassemia Treated With Ex Vivo Gene Therapy Using Autologous Hematopoietic St… Ended

2024-513905-29-00 Beta-thalassaemia 5 2008-10-16
A 24-week with possible extension, prospective, multicenter, randomized, double blind, placebo-controlled, 2-parallel group with a randomiza… Halted

2024-514538-19-00 Mastocytosis 5 2025-11-26
A study of AZD2962, an IRAK4 inhibitor, in Participants with Haematologic Neoplasms Halted

2025-520786-44-00 Myelodysplastic syndromes 7 2025-10-21
Salvage Therapy for Patients with Inadequate Response to Standard of Care Therapy in Granulomatosis with Polyangiitis Halted

2024-516687-28-00 Patients with GPA and inadequate response to standard o 5 2025-06-06
A Phase 1/2 Study to Assess the Safety, Pharmacokinetics, and Efficacy of Daily Intravenous of AB8939 in patients with Relapsed/Refractory A… Halted

2024-516641-39-00 Acute Myeloid Leukemia 7 2024-12-02
A 24-week, multicenter, randomized, double blind, placebo-controlled, dose-range finding phase II study to compare efficacy and safety of or… Halted

2024-515193-27-00 Mast cell activation syndrome 4 2024-09-19
A trial to understand if AZD0486 is safe and helps in people with Relapsed or Refractory B-cell acute lymphoblastic leukemia (B-ALL) Halted

2023-505840-20-00 B-Cell Acute Lymphoblastic Leukaemia 9 2024-08-16
A Trial to Study if REGN5837 in Combination with Odronextamab is Safe for Adult Participants with Aggressive B-cell Non-Hodgkin Lymphomas Halted

2022-502137-26-00 B-cell Non-Hodgkins Lymphoma (B-NHL) 1 2024-05-03
A phase I/II post-cord blood HCT dendritic cell vaccination trial directed against WT1 for pediatric and young adult acute myeloid leukemia:… Halted

2024-517922-24-00 AML: Acute Myeloid Leukemia/ cancer of blood and bone m 1 2023-12-06
To Investigate whether the combination of molidustat and an IDH1 inhibitor (ivosidenib) effectively inhibits leukaemia cells in patients wit… Halted

2024-514051-15-00 Adult patients with relapsed or refractory IDH1-mutated 7 2023-07-10