Phase I – First Administration to Humans

783 trials 323 recruiting

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A phase I trial evaluating the safety, tolerability, and pharmacokinetic profile of INP12 in patients with advanced solid tumors. Recruiting

2024-518126-32-00 Patients with advanced solid tumors. 2022-09-15
A prospective, single-center phase I pilot study to assess the tissue activity of multidrug resistance-associated protein 1 with positron em… Recruiting

2024-517851-11-00 Investigation in healthy volunteers and Alzheimer's dis 2022-09-05
A Phase 1, Open-Label, Multicenter Study of INCB123667 as Monotherapy and in Combination With Anticancer Therapies in Participants With Sele… Recruiting

2024-512822-28-00 Advanced or metastatic solid tumors 2022-08-08
A Phase 1a/1b Study of ELVN-001 for the Treatment of Chronic Myeloid Leukemia Recruiting

2023-503335-18-00 Chronic myeloid leukemia 2022-07-29
A First-in-Human Study to Evaluate the Safety and Tolerability of ALN-APP in Patients with EOAD Recruiting

2023-508363-79-00 Early-onset Alzheimer's disease (EOAD) 2022-06-29
Trial of the novel peroral anti-tumor treatment in patients with solid tumors Recruiting

2024-511215-21-00 Metastatic or locally advanced solid tumors for which n 2022-06-07
Clinical trial evaluating the safety, tolerability, and preliminary efficacy of BNT116 alone and in combinations in patients with advanced n… Recruiting

2023-509283-14-00 Advanced non-small cell lung cancer 2022-04-25
A Phase 1 First-in-Human Study of the Safety and Effects of VIR-5818 Alone or with Pembrolizumab in Participants with Advanced or Metastatic… Recruiting

2024-516010-38-00 Participants with Locally Advanced or Metastatic HER2-E 2022-04-25
A phase I study of the mesothelin x cd47 antibody NI-1801, as single agent and in combination with anti-pd-1 antibody, or with paclitaxel al… Recruiting

2024-517752-35-00 Advanced, metastatic, or recurrent solid mesothelin-exp 2022-04-04
HTLP-onco-adult - A phase I/II Study evaluating the safety and the efficacy of Human T Lymphoid Progenitor (HTLP) injection to accelerate im… Recruiting

2024-516104-42-00 hematologic malignancies ; acute myeloid leukemias 2022-02-17
A Safety Study of PF-08046040/SEA-CD70 in Patients with Myeloid Malignancies Recruiting

2023-506945-42-00 Acute myeloid leukaemia 2022-01-21
A Study with ABBV-CLS-484 Alone and in Combination in Subjects with Advanced Tumor Cancer Recruiting

2023-507568-38-00 Metastatic or locally advanced tumors 2022-01-14
Phase 1 Study of MK-1084 in KRAS mutant advanced solid tumors Recruiting

2022-501563-40-00 Solid tumor cancer and lung cancer 2021-12-16
A dose escalation followed by dose expansion trial to assess safety and tolerability of CAP-100 in subjects with relapsed/refractory chronic… Recruiting

2024-516341-39-00 Relapsed/refractory chronic lymphocytic leukemia (CLL) 2021-08-23
Beamion LUNG-1: A study to test different doses of zongertinib in people with different types of advanced cancer (solid tumours with changes… Recruiting

2024-511246-39-00 Solid tumours with HER2 aberrations 2021-07-27
CART19 cells effects in patients with relapsed/refractory acute lymphoblastic leukemia and non-Hodgkin lymphoma. Recruiting

2024-510815-30-00 Relapsed/refractory CD19+ Acute Lymphoblastic Leukaemia 2021-06-02
A Study to Investigate the Safety, Tolerability, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of RO7121932 following Intravenous a… Recruiting

2023-509357-31-00 Multiple Sclerosis (MS) 2021-06-01
CLEVER PEPTIDE : Open-label, non-controlled, multicenter, dose escalation, first-in-human clinical trial to evaluate the safety, pharmacokin… Recruiting

2024-518362-27-00 Patients with recurrent and/or metastatic solid cancer. 2021-05-18
PHASE I STUDY TO DETERMINE THE MAXIMUM TOLERATED DOSE FOR TRICHOSTATIN A IN SUBJECTS WITH RELAPSED OR REFRACTORY HEMATOLOGIC MALIGNANCIES Recruiting

2024-518454-17-00 relapsed/refractory hematologic malignancies 2021-01-08
A First-in-Human Study to Evaluate the Safety and Anti-cancer Activity of the product FS222, which is an Antibody medication, in Subjects wi… Recruiting

2024-514010-12-00 Advanced Malignancies 2020-12-03
A Study of Sigvotatug Vedotin in Advanced Solid Tumors Recruiting

2023-508469-34-00 Esophageal cancer 2020-10-14
A clinical study of the safety and effectiveness of an investigational cell therapy given with and without an investigational RNA-based vacc… Recruiting

2024-514962-38-00 Solid Tumors 2020-08-25
A study to test different doses of obrixtamig (BI 764532) in patients with small cell lung cancer and other neuroendocrine tumours that are … Recruiting

2024-513100-34-00 Small Cell Lung Carcinoma and other neuroendocrine neop 2020-07-15
Safety and Early Signs of Efficacy of IL12-L19L19 Recruiting

2024-510841-32-00 Advanced or metastatic carcinomas after previous immune 2020-05-27