Phase I – First Administration to Humans

783 trials 323 recruiting

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A STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF COR-1389 Recruiting

2024-514853-31-00 Obesity / Right heart failure (healthy participants) 2024-09-10
A study to test the biological properties of RO7568282 and whether it is safe in healthy participants and participants with Parkinson’s dise… Recruiting

2024-511110-21-00 Parkinson’s Disease 2024-09-09
A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 in Patients with Advanced or Metastatic Prostate Cancer Recruiting

2023-504013-68-00 Advanced or Metastatic Prostate Cancer 2024-09-06
In vivo quantification of Hsp90 in the human brain in healthy aging and neurodegeneration using the novel PET radioligand [11C]HSP990 Recruiting

2023-510532-36-00 Alzheimer's Disease 2024-09-04
Phase 1 Study of PYX-201 in Solid Tumors Recruiting

2023-509687-14-00 Advanced solid tumors 2024-08-29
An ascending dose study to determine the safety and effect of antibodies against hepatitis B (The SAMBA Study) Recruiting

2023-508444-22-01 Chronic hepatitis B infection 2024-08-26
An Open-Label, Multicenter, Multi-Arm Phase 1 Study Evaluating the Safety and Pharmacokinetics of ADU-1805 in Adults with Advanced Solid Tum… Recruiting

2022-502757-34-00 Advanced solid tumors 2024-08-20
First-in-human study of 225Ac-PSMA-Trillium (BAY 3563254) in participants with advanced metastatic castration-resistant prostate cancer (mCR… Recruiting

2023-507486-26-00 Advanced metastatic castration-resistant prostate cance 2024-08-20
First-in-human (FIH), microdosing, non-randomized, clinical trial to investigate binding of positron emission tomography tracer [68Ga]Ga-DOT… Recruiting

2023-506555-15-00 Metabolic dysfunction-associated steatotic liver diseas 2024-08-19
ADP-TILIL7 Recruiting

2023-509665-20-00 Locally advanced or metastatic melanoma 2024-08-15
Dendritic cell therapy combined with surgery in mesothelioma (ENSURE) Recruiting

2024-514054-70-00 Adult patients diagnosed with resectable epithelioid MP 2024-08-12
Phase 1/2a study of ATX-01 in participants with DM1 Recruiting

2023-505363-37-00 Myotonic dystrophy type 1 (DM1) 2024-08-12
First-in-Human Study of OKI-219 Alone and in Combination with Other Therapies in Patients with Solid Tumors / Breast Cancer Recruiting

2023-508435-31-00 Advanced Solid Tumors, Advanced Breast Cancer 2024-08-09
First-in human, dose escalation and cohort expansion study for the evaluation of LB-208 (HTR1B antagonist) in adult patients with relapsed o… Recruiting

2023-509532-25-00 Solid tumor 2024-08-07
A Phase 1, Open-Label, Multicenter, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preli… Recruiting

2023-506199-28-00 Dose escalation: Advanced Solid Tumors Dose Expansion: 2024-08-05
PHASE Ib STUDY WITH THE COMBINATION OF LB–100 (PP2A INHIBITOR) AND ATEZOLIZUMAB (PD–L1 INHIBI-TOR) IN METASTATIC COLORECTAL CANCER PATIENTS … Recruiting

2023-505534-98-00 Microsatellite stable colorectal cancer patients 2024-08-01
A Phase 1 Study of JNJ-88549968, a T-cell Redirecting Antibody, for CALR-mutated Myeloproliferative Neoplasms Recruiting

2023-505584-36-00 CALR-mutated Myeloproliferative Neoplasms 2024-07-30
A PHASE I STUDY OF XXX AS SINGLE AGENT OR IN COMBINATION WITH ANTI-PD-1 ANTIBODY IN SOLID CANCERS AND A RANDOMIZED COHORT EXPLORING THE COMB… Recruiting

2024-512175-12-00 Low tumour volume (LTV) advanced, metastatic, or recurr 2024-07-29
A study to assess safety and efficacy of SOT201 in patients with advance/metastatic cancer Recruiting

2023-504330-21-00 advanced/metastatic solid tumors 2024-07-22
A first-in-human study of the safety of an immunosuppressive antibody (IMP761) in healthy volunteers. Recruiting

2024-510761-42-00 autoimmunity 2024-07-17
A randomized double-blind placebo-controlled first-in-man single-dose and multiple dose study to evaluate the safety, tolerability and effic… Recruiting

2023-507737-17-00 Nasal colonization with methicillin-susceptible Staphyl 2024-07-10
A study of ASP2138 given by itself or given with other cancer treatments in adults with stomach cancer, gastroesophageal junction cancer, or… Recruiting

2023-504514-29-00 Gastroesophageal Junction (GEJ) Adenocarcinoma 2024-06-18
A Phase 1 study of JNJ-87704916, a tumor-targeting virus, injected into tumor for advanced cancer Recruiting

2023-506495-27-00 Advanced solid tumors 2024-06-18
AML-VAC-XS15-01: Multi-peptide vaccination adjuvanted with the TLR1/2 ligand XS15 in acute myeloid leukemia (AML) patients who have achieved… Recruiting

2023-510316-39-00 acute myeolic leukemia 2024-06-10