Phase I – First Administration to Humans

783 trials 323 recruiting

Filter these 783 trials by condition, country, sponsor and more.

Open in Search →

A Phase 1, Open-Label, Multicenter Study of INCA033890 in Participants with Advanced or Metastatic Solid Tumors Recruiting

2022-502456-31-00 Advanced or metastatic solid tumors 2023-11-30
Safety, pharmacokinetics, and preliminary efficacy of VIR-5500 (AMX-500) in prostate cancer Recruiting

2023-503495-24-00 Hormone-refractory prostate cancer 2023-10-30
A Phase 1/2 Study of the CTPS1 Inhibitor STP938 in Adult Subjects with Relapsed/Refractory B Cell and T-Cell Lymphomas Recruiting

2022-502299-21-00 Relapsed/refractory (R/R) B-cell and T-cell lymphomas 2023-10-18
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies Recruiting

2023-510541-25-00 Relapsed/Refractory B-cell Malignancies 2023-10-09
FusionVAC22_01: DNAJB1-PRKACA fusion transcript-based peptide vaccine combined with immune checkpoint inhibition for fibrolamellar hepatocel… Recruiting

2022-502869-17-01 tumor entities carrying the oncogenic driver fusion DNA 2023-09-26
A Phase 1 study of LOXO-435 in Locally Advanced or Metastatic Solid Tumors with FGFR3 Gene Alterations Recruiting

2022-502755-59-00 Locally Advanced or Metastatic Solid Tumors with FGFR3 2023-08-30
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination with Checkpoint Inhibitor i… Recruiting

2023-504709-35-00 Locally advanced or metastatic solid tumors 2023-08-16
A trial to test if different amounts of KTX-1001 are safe and tolerable in people with the bone marrow cancer multiple myeloma that has come… Recruiting

2022-500801-41-00 Relapsed and Refractory Multiple Myeloma 2023-07-26
Phase 1 Study of Allo-RevCAR01-T-CD123 in Patients With Selected CD123 Positive Hematologic Malignancies Recruiting

2022-501797-19-00 Acute Myeloid Leukemia (AML) 2023-07-13
SECRET-HF: Treatment of Non-ischemic Dilated Cardiomyopathies by Intravenous Infusions of the Extracellular Vesicle-Enriched Secretome of Ca… Recruiting

2024-512231-72-00 Non-ischemic Dilated Cardiomyopathies 2023-05-31
First-in-human study of OT-A201 in patients with selected hematological malignancies and solid tumors Recruiting

2024-511936-28-00 Relapsed/refractory hematological malignancies or adva 2023-05-12
A Phase 1 Study to Determine the Safety, and Pharmacokinetics of the Selective MET kinase Inhibitor, DO-2 in Patients With Advanced or Refra… Recruiting

2023-504897-39-00 Advanced or refractory solid tumours (Part 1) 2023-04-13
MIRROR; Multispectral and bimodal fluorescent guided surgery (FGS) of high-grade glioma for refining margin assessment: A phase 1 dose findi… Recruiting

2024-513392-40-01 Glioblastoma 2023-03-31
Phase 1 Study of AMG 509 in Subjects With Metastatic Castration-Resistant Prostate Cancer Recruiting

2023-504361-23-00 Metastatic Castration-Resistant Prostate Cancer (mCRPC) 2023-03-30
An open-label, multicentre, dose-escalation, first-in-human phase I study to evaluate safety, tolerability and antineoplastic activity of OA… Recruiting

2024-510836-31-00 Advanced and/or metastatic solid tumours (colorectal ca 2023-02-14
A Study of ImmunoPet Imaging Using 89Zr-DFO-REGN5054 in Adult Participants with Solid Cancers Treated with Cemiplimab Recruiting

2024-515351-37-00 Advanced Solid Tumor 2023-02-07
Coadministration of GA2 Sporozoites With Adjuvants (CoGA) Recruiting

2024-516488-99-00 Falciparum malaria 2023-02-03
Safety and efficacy of hCD1a-CAR T (OC-1) therapy, in patients with relapsed/refractory (R/R) T-cell acute lymphoblastic leukemia/lymphoma (… Recruiting

2024-514591-40-00 T-cell Acute Lymphoblastic Leukemia 2023-01-31
Clinical study to test the safety, tolerance and preliminary efficacy of oral ITF3756 administered alone or in combination with an anti-prot… Recruiting

2022-501089-22-00 Advanced solid tumors 2022-11-29
A First-in-Human Dose Escalation Study of JNJ-79635322, in Participants with Relapsed or Refractory Multiple Myeloma or Previously Treated A… Recruiting

2023-503679-12-00 Relapsed or Refractory Multiple Myeloma 2022-11-21
Phase I study to evaluate the safety, tolerability and preliminary efficacy of the bispecific PSMAxCD3 antibody CC 1 in men with biochemical… Recruiting

2024-511430-12-00 Prostate cancer recurrent 2022-11-11
First-in-Human Study of RLY-2608 in Advanced Breast Cancer and Other Solid Tumors. Recruiting

2022-500264-35-00 Advanced solid tumor with a PIK3CA mutation in blood an 2022-10-28
Phase 1 dose-escalation trial of OMTX705, an anti-fibroblast activation protein antibody-drug conjugate, as single agent and in combination … Recruiting

2024-514746-36-00 Selected tumor indications that are known to express FA 2022-10-20
A first-in-human, phase I, single-center, open-label, dose-escalation trial in healthy volunteers to assess safety, tolerability, and immuno… Recruiting

2024-511493-67-00 Prophylactic vaccination against HPV in healthy volunte 2022-10-07