Immune System Diseases

905 trials 381 recruiting

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A Phase 1 Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants with Severe, Refractory Autoimmune Diseases Recruiting

2024-517681-41-00 Systemic Sclerosis 1 2025-08-29
A study to evaluate how well single and multiple doses of O3R-5671-PRO are tolerated in healthy adult subjects Recruiting

2025-522571-28-00 Inflammatory bowel diseases and psoriasis. 1 2025-08-28
Prospective diagnostic performance of PET/CT using the novel fibroblast imaging tracer 18F-AlF-FAPI-74 versus standard of care 18F-FDG in in… Recruiting

2024-516464-28-00 Fever of unknown origin/Inflammation of unknown origin 10 2025-08-27
Safety, Tolerability, and Efficacy of NVG-2089 in Participants with Immune Thrombocytopenia Recruiting

2024-520359-26-00 Immune Thrombocytopenia (ITP) 4 2025-08-20
A study to investigate the efficacy, safety, and pharmacokinetics of oral rilzabrutinib compared with placebo in participants 18 years of ag… Recruiting

2024-517972-39-00 Autoimmune haemolytic anaemia 5 2025-08-19
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Daily Piclidenoson (CF101) Administered Orally i… Recruiting

2024-519919-34-00 Plaque psoriasis 5 2025-08-18
A Phase I/II Double-blind, randomized, placebo-controlled trial to preserve residual insulin secretion in children with recent onset Type 1 … Recruiting

2024-515106-30-00 Type 1 diabetes 9 2025-08-06
A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults with Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE) Recruiting

2024-517529-26-00 Chronic Inflammatory Demyelinating Polyneuropathy 5 2025-08-04
A phase I/II study of CAR-expressing Allogenic iPSC derived NK cells for treatment of autoiMmune disease by B cELl depletion - CARAMEL Recruiting

2024-519532-16-00 Idiopathic inflammatory myositis 9 2025-07-30
Trial to Evaluate the Long-term Safety and Efficacy of Avacopan in participants With ANCA-associated Vasculitis Recruiting

2023-503184-42-00 Antineutrophil cytoplasmic antibody-associated vasculit 6 2025-07-28
A Phase 2 Multicenter, Randomized, Platform Study of Targeted Therapies for the Treatment of Adult Subjects with Active Psoriatic Arthritis Recruiting

2024-519291-11-00 Psoriatic Arthritis 4 2025-07-25
Comparison of the effects of Belatacept and Anticalcineurins on endothelial function in kidney transplant patients - BELAFENDO Recruiting

2024-515577-10-00 Kidney transplant 6 2025-07-24
Phase 3 Study of Ravulizumab versus Placebo in Adult Participants at High Risk of DGF after Kidney Transplantation (AWAKE) Recruiting

2024-517568-48-00 Delayed Graft Function after Kidney Transplantation 5 2025-07-21
A Study to Learn How the Study Medicine Called Etrasimod is Taken up Into Blood and Breastmilk of Healthy Breastfeeding Women. Recruiting

2025-520930-44-00 Ulcerative Colitis and immune-mediated inflammatory dis 3 2025-07-18
Prevention of secondary infections by interferon gamma in ICU-acquired sustained immune-suppression: a randomized trial Recruiting

2024-516780-93-00 Sustained immunosuppression 5 2025-07-09
Comprehensive Evaluation of Two Second-Line Therapeutic Approaches for Immune Thrombocytopenia (ITP) – a Pragmatic Randomized Controlled Tri… Recruiting

2023-505573-32-00 Immune Thrombocytopenia (ITP) 5 2025-07-01
A 12-week randomized, participant and investigator blinded, placebo-controlled, exploratory study in adult participants with Chronic Urticar… Recruiting

2024-516355-41-00 Chronic Inducible urticaria and Chronic Spontaneous Urt 4 2025-06-30
A three-part trial in healthy volunteers to find out how long icotrokinra stays in and acts on the body when administered as different table… Recruiting

2025-521005-41-00 Inflammatory Conditions 3 2025-06-30
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants with Systemic Lupus Ery… Recruiting

2024-519015-34-00 Systemic Lupus Erythematosus 1 2025-06-30
A study to assess the efficacy and safety of efgartigimod PH20 SC in adults with systemic sclerosis (eSScape) Recruiting

2024-514539-67-00 Systemic Sclerosis 4 2025-06-27
A Phase 2b Study to Assess the Efficacy and Safety of IMVT-1402 in Patients with Grave’s Disease Recruiting

2024-516020-33-00 Grave’s Disease 4 2025-06-26
A Long-term Follow-up Study for Subjects Previously Treated with Autologous ex vivo Lentiviral Hematopoietic Stem and Progenitor Cell Gene T… Recruiting

2024-518369-92-00 Wiskott-Aldrich syndrome (WAS) 5 2025-06-25
Randomized controlled multicenter study comparing steroid therapy plus anticoagulants to steroid therapy alone in deep venous thrombosis of … Recruiting

2023-510262-27-00 newly diagnosed or relapsing deep venous thrombosis rel 4 2025-06-24
A study to assess safety, cellular kinetics and exploratory efficacy of rapcabtagene autoleucel in rheumatoid arthritis and Sjogren’s diseas… Recruiting

2024-514596-18-00 Difficult to treat rheumatoid arthritis 9 2025-06-20