Therapeutic Confirmatory (Phase III)

3,259 trials 1,319 recruiting

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A Phase III, Open-label, Single Arm, Prospective, Multicenter Study to Assess Efficacy and Safety of Kedrion Intravenous Human Normal Immuno… Recruiting

2023-507115-35-00 Chronic Immune Thrombocytopenia (ITP) 2025-11-03
T3-4-Hypo trial Recruiting

2024-513883-24-00 Hypothyroidism Triiodothyronine Quality of Life Persist 2025-11-02
The efficacy and safety of Intramuscular Methylprednisolone in patients with Hand OsteoArthritis: the IMHOA trial Recruiting

2024-518344-20-00 Hand osteoarthritis 2025-10-28
Study to assess the pharmacokinetics, safety, and tolerability of iptacopan in pediatric PNH patients Recruiting

2024-515926-10-00 Paroxysmal Nocturnal Hemoglobinuria (PNH) 2025-10-28
A multicenter, prospective, randomized, double blind, placebo controlled, adaptive design study performed to evaluate the efficacy and the s… Recruiting

2024-519623-23-00 Venous leg ulcer 2025-10-20
A Study to Assess the Adverse Events, Effectiveness, and How the Drug Moves through the Body of Intravenous and Subcutaneous Injections of R… Recruiting

2024-514695-41-00 Ulcerative Colitis 2025-10-17
An Open-label, Randomized, Phase 3 Study to Evaluate Patritumab Deruxtecan Monotherapy versus Treatment of Physician’s Choice in Hormone Rec… Recruiting

2025-520582-51-00 Hormone receptor positive breast cancer 2025-10-17
Vedolizumab Subcutaneous Long-term Open-label Extension Study in Pediatric Subjects Recruiting

2023-508804-39-00 Ulcerative Colitis or Crohn’s Disease 2025-10-15
A Phase 3 Open-Label Study to Investigate bexicaserin (LP352) in Children and Adults with Developmental and Epileptic Encephalopathy Recruiting

2024-514974-39-00 Developmental and Epileptic Encephalopathies (DEEs) 2025-10-10
A Phase 3 Single-arm Study of UGN-104 for the Treatment of LG-UTUC Recruiting

2024-519343-15-00 Low-grade Upper Tract Urothelial Cancer 2025-10-08
Long-term study to assess the safety and tolerability of adjunctive NBI-1065845 in adults with Major Depressive Disorder (MDD) Recruiting

2024-519423-24-00 Major Depressive Disorder 2025-10-07
The efficacy and safety of rilzabrutinib in participants aged 10 to 65 years with sickle-cell disease Recruiting

2024-518645-17-00 Blood and lymphatic diseases 2025-10-07
A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab vs Chemotherapy plus Pembrolizumab as First-Line Treatment o… Recruiting

2023-508056-19-00 HER2-Expressing (IHC 3+/IHC 2+), Mismatch Repair Profi 2025-10-02
A clinical study of MK-7240 for the treatment of Crohn’s disease (MK-7240-008) Recruiting

2024-518296-56-00 Crohn’s Disease 2025-09-29
A Phase 3 Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder Recruiting

2024-520195-94-00 BP-I mania or mania with mixed features 2025-09-25
A Phase 3 Open-label Extension Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder Recruiting

2024-520259-26-00 Mania or Mania with Mixed Features in Bipolar-I Disorde 2025-09-25
Phase 3 Study of T-DXd and Rilvegostomig versus Standard of Care in Advanced HER2-expressing Biliary Tract Cancer Recruiting

2023-508057-19-00 Advanced HER2-expressing Biliary Tract Cancer 2025-09-23
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obe… Recruiting

2024-520209-38-00 Obesity or Overweight 2025-09-19
An RCT investigating hCG priming in women with diminished ovarian reserve Recruiting

2025-521234-28-00 Infertility, diminished ovarian reserve. 2025-09-10
A study to compare pharmacokinetics, efficacy, safety, and immunogenicity of MB12 (proposed pembrolizumab biosimilar) to Keytruda® in non-sm… Recruiting

2024-515853-48-00 advanced/metastatic non-squamous non-small cell lung ca 2025-09-05
Selective Treatment of Oral Povorcitinib Long-Term Rollover Study (STOP-LTR) Recruiting

2024-520107-12-00 Hidradenitis Suppurativa // Prurigo Nodularis // Vitili 2025-09-03
A Worldwide Study Testing the New Drug Lisaftoclax for Patients with Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma… Recruiting

2024-514084-26-00 Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymp 2025-08-22
The AIRTIVITY TM Study: A study to find out whether BI 1291583 helps people with bronchiectasis Recruiting

2024-518589-29-00 Bronchiectasis 2025-08-21
Assess the safety and efficacy of sovateltide in patients with acute cerebral ischemic stroke. Recruiting

2024-519551-29-00 Acute cerebral ischemic stroke 2025-08-21