ACTIVATE - Phase 1 Clinical Trial evaluating the combination of Actinomycin D and venetoclax in patients with Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

2025-524728-22-01 Protocol APHP251246 Phase I and Phase II (Integrated) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 6 sites · Protocol APHP251246

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - Other
Status Authorised, recruitment pending
Participants planned 36
Countries 1
Sites 6

Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

Key facts

Sponsor
Assistance Publique Hopitaux De Paris
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Not possible to specify, Diseases [C] - Hemic and Lymphatic Diseases [C15], Diseases [C] - Neoplasms [C04]
Decision date (initial)
2026-06-10
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Assistance Publique Hopitaux De Paris

Sponsor organisation
Assistance Publique Hopitaux De Paris
Address
Porte 23, 1 Avenue Claude Vellefaux 1 Avenue Claude Vellefaux
City
Paris Cedex 10
Postcode
75475
Country
France

Scientific contact point

Organisation
Assistance Publique Hopitaux De Paris
Contact name
Dr Sofiane Fodil

Public contact point

Organisation
Assistance Publique Hopitaux De Paris
Contact name
Dr Sofiane Fodil

Locations

1 EU/EEA country · 6 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Authorised, recruitment pending 36 6
Rest of world 0

Investigational sites

France

6 sites · Authorised, recruitment pending
Institut Gustave Roussy
Hematology, 39 Rue Camille Desmoulins, 94805, Villejuif Cedex
Assistance Publique Hopitaux De Paris
Hematology, 1 Avenue Claude Vellefaux, 75010, Paris
Institut Paoli Calmettes
Hematology, 232 Boulevard De Sainte Marguerite, Bp 156, Marseille
Assistance Publique Hopitaux De Paris
Clinical Hematology, 125 Rue De Stalingrad, 93000, Bobigny
Centre Hospitalier Universitaire De Nice
Hematology, 151 Route De Saint Antoine, 06200, Nice
Assistance Publique Hopitaux De Paris
Hematology, 27 Rue Du Faubourg Saint Jacques, 75014, Paris

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-04-16 France Acceptable
2026-06-04
2026-06-10