Open-label study of BBO-11818 in adult subjects with KRAS mutant cancer

2025-524690-16-00 Protocol TBBO11818-101 Human pharmacology (Phase I) - First administration to humans Authorised, recruitment pending

Status Authorised, recruitment pending · 3 EU/EEA countries · 20 sites · Protocol TBBO11818-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Authorised, recruitment pending
Participants planned 3,999,996
Countries 3
Sites 20

Solid Tumors

Key facts

Sponsor
Theras Inc.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2026-06-18
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2025-524690-16-00
ClinicalTrials.gov
NCT06917079

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Solid Tumors

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Theras Inc.

Sponsor organisation
Theras Inc.
Address
256 East Grand Avenue Suite 104
City
South San Francisco
Postcode
94080-4811
Country
United States

Scientific contact point

Organisation
Theras Inc.
Contact name
CTIS Contact Point

Public contact point

Organisation
Theras Inc.
Contact name
CTIS Contact Point

Locations

3 EU/EEA countries · 20 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Authorised, recruitment pending 999,999 8
Italy Authorised, recruitment pending 999,999 5
Spain Authorised, recruitment pending 999,999 7
Rest of world
Turkey, Korea, Republic of, Taiwan, Brazil, United Kingdom, United States, Australia, Canada
999,999

Investigational sites

France

8 sites · Authorised, recruitment pending
Centre Hospitalier Regional De Marseille
Oncology, 264 Rue Saint Pierre, 13005, Marseille
Institut Regional Du Cancer De Montpellier
Oncology, 208 Avenue Des Apothicaires, 34298, Montpellier Cedex 5
Institut Bergonie
Oncology, 180 R De Saint Genes, 229 Cours De L Argonne, Bordeaux
Institut De Cancerologie De Lorraine
Oncology, 6 Avenue De Bourgogne, 54500, Vandouvre Les Nancy
Institut Gustave Roussy
Oncology, 114 Rue Edouard Vaillant, 94800, Villejuif
Centre Oscar Lambret
Oncology, 3 Rue Frederic Combemale, 59000, Lille
Hospices Civils De Lyon
Oncology, 165 Chemin Du Grand Revoyet, 69310, Pierre Benite
Institut Curie
Oncology, 26 Rue D Ulm, 75005, Paris

Italy

5 sites · Authorised, recruitment pending
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
UOC Fase 1, Largo Francesco Vito 1, 00168, Rome
Ospedale San Raffaele S.r.l.
Oncologia Medica, Via Olgettina 60, 20132, Milan
Istituto Europeo Di Oncologia S.r.l.
Divisione Sviluppo di nuovi farmaci per terapie innovative, Via Giuseppe Ripamonti 435, 20141, Milan
IRCCS Istituto Nazionale Tumori Fondazione Pascale
Melanoma Cancer Immunotherapy and Development therapeutics Unit, Via Mariano Semmola 52, 80131, Naples
Istituto Oncologico Veneto
Oncologia, Via Gattamelata 64, 35128, Padova

Spain

7 sites · Authorised, recruitment pending
Hospital Universitari Vall D Hebron
Oncology, Passeig De La Vall D'Hebron 119-129, 08035, Barcelona
Hospital Hm Nou Delfos
Oncology, Avinguda De Vallcarca 151, 08023, Barcelona
Hospital Universitario Quironsalud Madrid
Oncology, Calle De Diego De Velazquez 1, 28223, Pozuelo De Alarcon
Hospital Universitario Fundacion Jimenez Diaz
Oncology, Avenida De Los Reyes Catolicos 2, 28040, Madrid
Hospital Universitario Miguel Servet
Oncology, Paseo De Isabel La Catolica 1-3, 50009, Zaragoza
Hospital Universitario Y Politecnico La Fe
Oncology, Avenida Fernando Abril Martorell 106, 46026, Valencia
Hospital Universitario Hm Sanchinarro
Oncology, Calle Ona 10, 28050, Madrid

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-02-27 Spain Acceptable
2026-06-15
2026-06-16
2 NON SUBSTANTIAL MODIFICATION NSM-1 2026-06-24 Acceptable
2026-06-15
2026-06-24