A study to learn more about how safe BAY 3771249 is and how well it works in people with advanced or metastatic colorectal cancer that has a KRAS G12D mutation

2025-523648-11-00 Protocol 23111 & 23111-1 Human pharmacology (Phase I) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 7 EU/EEA countries · 9 sites · Protocol 23111 & 23111-1

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruitment pending
Participants planned 130
Countries 7
Sites 9

adenocarcinoma of the colon or rectum

Key facts

Sponsor
Bayer Consumer Care AG
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2026-06-12
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

adenocarcinoma of the colon or rectum

VersionLevelCodeTermSystem organ class
21.0 PT 10052360 Colorectal adenocarcinoma 100000004864

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Bayer Consumer Care AG

Sponsor organisation
Bayer Consumer Care AG
Address
Peter Merian-Strasse 84
City
Basel
Postcode
4052
Country
Switzerland

Scientific contact point

Organisation
Bayer Consumer Care AG
Contact name
Therapeutic Area Head

Public contact point

Organisation
Bayer Consumer Care AG
Contact name
Therapeutic Area Head

Locations

7 EU/EEA countries · 9 investigational sites

By country

CountryMS statusPlanned subjectsSites
Belgium Authorised, recruitment pending 7 1
Denmark Authorised, recruitment pending 10 2
Finland Authorised, recruitment pending 4 1
Italy Authorised, recruitment pending 10 1
Netherlands Authorised, recruitment pending 4 1
Spain Authorised, recruitment pending 7 2
Sweden Authorised, recruitment pending 7 1
Rest of world
United States, Singapore, Australia
81

Investigational sites

Belgium

1 site · Authorised, recruitment pending
Universitair Ziekenhuis Gent
Drug Research Unit Department, Corneel Heymanslaan 10, 9000, Gent

Denmark

2 sites · Authorised, recruitment pending
Rigshospitalet
Kræftbehandling, Blegdamsvej 9, 2100, Copenhagen Oe
Odense University Hospital
Oncology Department, J. B. Winsloews Vej 4, 5000, Odense C

Finland

1 site · Authorised, recruitment pending
HUS-yhtymae
Syöpäkeskus, Haartmaninkatu 4, 00290, Helsinki

Italy

1 site · Authorised, recruitment pending
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
UOC Fase I, Largo Francesco Vito 1, 00168, Rome

Netherlands

1 site · Authorised, recruitment pending
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Nederlands Kanker Instituut, Plesmanlaan 121, 1066 CX, Amsterdam

Spain

2 sites · Authorised, recruitment pending
Hospital Universitari Vall D Hebron
Oncologia, Passeig De La Vall D'Hebron 119-129, 08035, Barcelona
Hospital Universitario Hm Sanchinarro
Oncologia, Calle Ona 10, 28050, Madrid

Sweden

1 site · Authorised, recruitment pending
Karolinska University Hospital
Tema Cancer, Eugeniavagen 3, 171 64, Solna

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-02-23 Denmark Acceptable
2026-06-08
2026-06-08