A phase 1 first-in-human study of a phenylalanine-binding polymer (phelimin) in healthy volunteers and adult, classical PKU patients

2024-519121-38-01 Protocol SMR-4023 Human pharmacology (Phase I) - First administration to humans Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol SMR-4023

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Authorised, recruitment pending
Participants planned 7
Countries 1
Sites 1

Phenylketonuria

Key facts

Sponsor
Mipsalus ApS
Participant type
Healthy volunteers, Patients
Age range
18-64 years
Gender
Male
Therapeutic area
Diseases [C] - Nutritional and Metabolic Diseases [C18]
Decision date (initial)
2026-06-17
Transition trial
No
Low-intervention
No
Rare-disease indication
Yes
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Phenylketonuria

VersionLevelCodeTermSystem organ class
20.0 PT 10034872 Phenylketonuria 100000004850

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Mipsalus ApS

Sponsor organisation
Mipsalus ApS
Address
Agern Alle 3
City
Hoersholm
Postcode
2970
Country
Denmark

Scientific contact point

Organisation
Mipsalus ApS
Contact name
Clinical Operations

Public contact point

Organisation
Mipsalus ApS
Contact name
Clinical Operations

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Denmark Authorised, recruitment pending 7 1
Rest of world 0

Investigational sites

Denmark

1 site · Authorised, recruitment pending
Rigshospitalet
Centre Inherited Metabolic Diseases, Dept. Pediatrics and Clinical Genetics, Blegdamsvej 9, 2100, Copenhagen Oe

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-05-05 Denmark Acceptable
2026-06-16
2026-06-17