Therapeutic Exploratory (Phase II)

3,454 trials 1,368 recruiting

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A phase 2b clinical trial to evaluate efficacy and safety of weekly doses of TransCon CNP compared with placebo in participants with achondr… Ended

2024-515469-32-00 Achondroplasia in Children and Adolescents 2023-03-02
A phase IIa, open label, Single-centre study to assess the initial antifibrotic efficacy, safety, tolerability, pharmacokinetic and pharmaco… Ended

2022-501464-18-00 Crohn’s disease 2023-03-01
A Study of LY3473329 in Adult Participants With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events ( KRAKEN ) Ended

2022-501466-21-00 Lipoprotein Disorder 2023-03-01
A study to evaluate the long-term safety and tolerability of pimavanserin after 52 weeks of treatment in children and adolescents with ASD Ended

2024-512202-25-00 Irritability associated with autistic disorder in child 2023-02-27
A Open-label Study to Evaluate the Efficacy, Safety, Tolerability of HZN-825 in Patients with Diffuse Cutaneous Systemic Sclerosis Ended

2023-509783-23-00 Diffuse Cutaneous Systemic Sclerosis 2023-02-24
A Phase 2 Study to Evaluate Efficacy, Safety, and Pharmacokinetics of PBF-999 in the Treatment of Patients with Prader-Willi Syndrome. Ended

2022-501462-22-00 Prader-Willi Syndrome 2023-02-22
A Parallel-group (2-Arm), Randomized, Double-blind, 12-week Trial to Evaluate the Efficacy and Safety of MC2-25 Cream and MC2-25 Vehicle in… Ended

2022-500044-38-01 Chronic Kidney Disease associated Pruritus 2023-02-20
Theophylline Effects in the Fontan Circulation Ended

2022-500301-41-00 Univentricular congenital heart disease with a Fontan-t 2023-02-20
Multiple Dose Study to Evaluate Efficacy, Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of MYK-224 in Participants with Sympto… Ended

2023-508831-29-00 Symptomatic Hypertrophic Cardiomyopathy and Left Ventri 2023-02-15
A Phase 2a/2b Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of MK-1942 as Adjunctive Therapy in Particip… Ended

2023-504017-79-00 Treatment of AD dementia 2023-02-14
A Phase 2 Study of MORAb-202 in Platinum-resistant High-grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Ended

2023-504111-33-00 Platinum-resistant High-grade Serous Ovarian, Primary P 2023-02-14
A Study of Multiple Doses of RO7247669 in Participants With Previously Untreated Unresectable or Metastatic Melanoma Ended

2023-505672-30-00 Unresectable or Metastatic Melanoma 2023-02-10
A Study of LY3819469 in Participants With Elevated Lipoprotein(a) [Lp(a)] Ended

2022-501426-38-00 Lipoprotein Disorder 2023-02-09
Clinical investigation evaluating safety and efficacy of selective intra-arterial 166Holmium radiation therapy in combination with atezolizu… Ended

2024-511538-11-00 Non resectable Hepatocellular carcinoma (HCC) 2023-02-07
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Study to Assess the Efficacy, Safety, Tolerability, PK, and Biomarker Effe… Ended

2023-510317-26-00 Amyotrophic Lateral Sclerosis 2023-02-07
A proof-of-concept study to examine QUC398 in participants with knee osteoarthritis Ended

2023-509274-28-00 Knee osteoarthritis 2023-02-03
A study to learn how well the drug EDP-938 works and how safe it is for non-hospitalized Adults with Acute Respiratory Syncytial Virus Infec… Ended

2024-513861-38-00 Respiratory syncytial virus (RSV) 2023-02-02
Multicenter, Open-label, Single arm, Phase II Clinical Trial to Improve Sacituzumab Govitecan Tolerance in Patients with Metastatic Triple-N… Ended

2024-514060-10-00 Advanced triple-negative breast cancer (TNBC), Advanced 2023-02-02
Molecular PD-L1 PET/CT Imaging with 89Zr-atezolizumab to Monitor Immune Responses in metastatic Triple Negative Breast Cancer Ended

2022-500808-21-00 Metastatic triple negative breast cancer 2023-02-01
A 12-month, randomized, single-blind, placebo-controlled exposure-response study of TCD601 (siplizumab) in new onset type 1 diabetes patient… Ended

2023-506837-31-00 New onset type I diabetes 2023-01-27
A clinical study to learn whether a new drug, TPN-101, is safe when given to AGS patients Ended

2024-511176-32-00 Aicardi-Goutières Syndrome (AGS) 2023-01-27
Calcium electroporation in combination with irreversible electroporation and immunotherapy in patients with pMMR metastatic colorectal cance… Ended

2022-500045-25-00 Colorectal cancer 2023-01-26
Quercus ilex and Quercus robur allergen extracts. Determination of in the vivo histamine equivalent prick test units (HEP). Ended

2024-515189-14-00 Allergy to Quercus ilex and Quercus robur 2023-01-26
A multi-center study to evaluate the safety, tolerability and efficacy of TIN816 in patients at risk for acute kidney injury following a car… Ended

2024-511621-64-00 Acute kidney injury 2023-01-18