Phase I – First Administration to Humans

783 trials 323 recruiting

Filter these 783 trials by condition, country, sponsor and more.

Open in Search →

A phase 1, randomized, double-blind, single-center, placebo-controlled first-in-human trial to assess the safety, tolerability, pharmacokine… Halted

2023-510371-55-00 Complement-mediated diseases 2024-11-14
A study of PF-08046050 (SGN-CEACAM5C) in adults with advanced solid tumors Halted

2023-505858-18-00 Pancreatic carcinoma 2024-06-28
A Trial to Study if REGN5837 in Combination with Odronextamab is Safe for Adult Participants with Aggressive B-cell Non-Hodgkin Lymphomas Halted

2022-502137-26-00 B-cell Non-Hodgkins Lymphoma (B-NHL) 2024-05-03
Dosimetry of a novel amino acid PET tracer, [18F]FELP Halted

2022-501696-91-00 Glioblastoma 2024-04-10
A phase I/II post-cord blood HCT dendritic cell vaccination trial directed against WT1 for pediatric and young adult acute myeloid leukemia:… Halted

2024-517922-24-00 AML: Acute Myeloid Leukemia/ cancer of blood and bone m 2023-12-06
A phase 1 Clinical Trial to Evaluate Safety and Immunogenecity of HIV SOSIP v8.2 763 Vaccine in healthy individuals Ended

2025-520529-19-00 Human Immunodeficiency Virus (HIV) 2026-05-20
A clinical study of MK-6050 in healthy people (MK-6050-001) Ended

2025-523861-58-00 Hidradenitis suppurativa 2025-11-24
A study in healthy men to find out how different doses of BI 3009947 are tolerated and how different formulations or food influence how BI 3… Ended

2025-521095-66-00 Healthy volunteer trial 2025-11-19
A Phase 1 Study of ATV-1601, in Patients with Advanced Cancer that have AKT1 E17K Mutations Ended

2025-521480-12-00 Advanced solid tumors, Breast Cancer 2025-10-22
A clinical study of MK-4082 in healthy people (MK-4082-001) Ended

2025-522100-25-00 Weight management 2025-10-09
A First-in-human study to learn how safe the study drug BAY2965501 is, find the best dose (single drug & combination), how it affects the bo… Ended

2023-507905-33-00 Advanced solid tumors 2025-09-30
A study to investigate safety of INT2104 infusions in participants aged 18 years of age and older who have B-cell cancers that came back aft… Ended

2023-509132-26-00 Refractory/Relapsing B-Cell Malignancies 2025-08-08
Phase I, first-in-man, randomised, placebo-controlled, single dose escalation study to investigate the effects of LPH-5 on safety, tolerabil… Ended

2024-512330-15-00 Depression 2025-08-05
A Phase 1 Randomized, Placebo-Controlled, Double-Blind Study of the Safety, Tolerability and Pharmacological Effects of PT00114 in Healthy V… Ended

2024-519316-13-00 Phase I study in healthy male and female volunteers. In 2025-08-01
Jim Beam Cumulative Irritation Patch Test Ended

2025-520663-41-00 healthy volunteers 2025-07-21
A Study of PF-08046031 in Adults With Advanced Melanoma and Other Solid Tumors Ended

2024-514745-10-00 Melanoma (or) malignant melanoma Non-small cell lung ca 2025-06-23
A Phase 1a/1b Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of BG-60366 in Patien… Ended

2024-517322-26-00 EGFR-Mutant Non-Small Cell Lung Cancer 2025-06-06
A Study to Learn How Safe Different Doses of NTS-521 are, What the Amount of NTS-521 in the Body is Over a Period of Time, and What the Effe… Ended

2024-518613-26-01 Not applicable 2025-06-06
A study to assess the safety of ARGX-121 in Healthy Adult Participants Ended

2025-521524-30-00 Healthy volunteers 2025-06-05
A Study to Learn More About an Investigational Medicine called HDP-102 in Patients with Relapsed/Refractory B-cell Blood Cancers. Ended

2023-508759-38-00 Relapsed/Refractory B-cell Malignancies 2025-06-04
A clinical study of MK-1289 in healthy adult men (MK-1289-001) Ended

2025-521395-63-00 COVID-19 Infection 2025-06-04
A study investigating the safety, absorption, and elimination of NNC0705-0001, a new compound that could potentially be used in the treatmen… Ended

2024-519478-38-00 Cardiometabolic diseases with an inflammatory component 2025-06-03
A Study to Investigate the Safety and Effectiveness of RO7759065 in Combination with Atezolizumab in Participants with Locally Advanced or M… Ended

2024-513391-17-00 Locally Advanced or Metastatic Solid Tumors 2025-05-27
A Phase 1a/1b Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of the DG… Ended

2023-503996-38-00 Advanced or metastatic solid tumors 2025-05-21