Phase I/II – First Administration

453 trials 190 recruiting

Filter these 453 trials by condition, country, sponsor and more.

Open in Search →

A study to assess the safety and efficacy of AZD7789 in participants with advanced or metastatic solid cancer Ended

2022-502774-17-00 Advanced or metastatic gastric and gastro-esophageal ju 2021-10-04
REGN7257 in Adult Patients with Severe Aplastic Anemia That Is Refractory to or Relapsed on Immunosuppressive Therapy Ended

2023-508601-24-00 Severe aplastic anemia (SAA) 2021-09-13
First-in-Human Study of RLY-4008 in Patients With ICC and Other Advanced Solid Tumors Ended

2024-512622-29-00 Cholangiocarcinoma (CCA) and Other Advanced Solid Tumor 2021-09-10
A study of PRS-344/S095012 (PD-L1x4-1BB bispecific antibody) in patients with solid tumors Ended

2023-510046-25-00 Soild Tumors 2021-09-02
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE) Ended

2024-511728-15-00 Solid tumors 2021-08-26
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL310 in Pediatric Participants with Hunter Syndrome Ended

2023-508619-22-00 Hunter Syndrome (Mucopolysaccharidosis Type II [MPS II] 2021-06-22
A first-in-human clinical trial in adult patients with advanced non-small cell lung cancer of a personalised therapy targeting specific muta… Ended

2024-513060-26-00 Non-small cell lung cancer 2021-04-07
A Multicentre, Open-Label, Single Ascending Dose, Dose-Ranging, Phase I/IIa Study to Evaluate the Safety and Tolerability of an Autologous A… Ended

2024-512579-11-00 Prophylaxis against renal transplant rejection 2021-03-17
GEN3014 Trial in Relapsed or Refractory Hematologic Malignancies Ended

2023-507086-26-00 Relapsed or Refractory Multiple Myeloma (RRMM) Diffuse 2021-03-09
A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors Ended

2024-518529-14-00 Metastatic/advanced soft tissue sarcoma (STS), Merkel c 2021-02-26
Phase I/II trial of S65487 plus azacitidine in acute myeloid leukemia Ended

2023-510051-27-00 Acute Myeloid Leukemia (AML) 2021-02-25
A Phase I/IIb extension study assessing the long-term safety and efficacy of a gene therapy (AAV5-hFIX) previously administered to adult pat… Ended

2024-512603-39-00 Haemophilia B 2021-01-08
Phase I/II, First in Human, Dose Escalation Trial of TL-895 Monotherapy in Subjects with Relapsed/Refractory B-Cell Malignancies and Expansi… Ended

2024-516691-14-00 B Cell Malignancies and Chronic Lymphocytic Leukemia or 2021-01-05
A dose-esalation phase I/II study in patients with RAS-mutated metastatic colorectal cancer to investigate safety and clinical actvitiy of t… Ended

2023-509732-25-00 metastatic colorectal cancer with a proven RAS mutation 2020-07-31
Safety, immunogenicity and preliminary clinical activity study of PDC*lung01 cancer vaccine in NSCLC Ended

2024-517429-24-00 Non-small-cell lung cancer 2020-01-09
REGN5093 in Patients With MET-Altered Advanced Non-Small Cell Lung Cancer Ended

2023-506248-18-00 MET-altered non-small cell lung cancer (NSCLC) 2020-01-07
Botulinum toxin (BOTOX®) to prevent post-operative pancreatic fistula in patients who undergo distal pancreatectomy Ended

2024-517267-23-00 postoperative pancreatic fistulas 2019-11-11
An Early Phase Study with the Drug LOXO-305 in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL… Ended

2023-509270-37-00 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 2019-10-10
NeoRay - Phase I/IIa trial of [177Lu]-NeoB in patients with advanced solid tumors and with [68Ga]-NeoB lesion uptake. Ended

2023-507170-41-00 Solid tumors known to overexpress GRPR and with [68Ga]- 2019-07-29
A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specifi… Ended

2024-511798-31-00 KRAS p.G12C Mutant Advanced Solid Tumors 2019-05-31
An phase I study of BI 765063 (a monoclonal antibody) as single agent and in combination with BI 754091 (a PD-1) to characterize safety, pha… Ended

2024-519150-37-00 Patients with advanced solid tumour 2019-05-21
A Phase 1/2/3 Study to Evaluate the Safety and Efficacy of a Single Dose of Autologous CRISPR-Cas9 Modified CD34+ Human Hematopoietic Stem a… Ended

2024-516067-83-00 Severe sickle cell disease (SCD) 2019-05-02
"Safety, efficacy, immunogenicity study of GSK Biologicals’ HBV viral vector and adjuvanted proteins vaccine (GSK3528869A) in adult patients… Ended

2023-510020-68-00 Hepatitis B, Chronic 2019-03-18
A clinical gene therapy study with hematopoietic stem cells for the treatment of patients suffering from a malignant neoplasm of the central… Ended

2023-510299-29-00 Glioblastoma multiforme 2019-03-13