Temozolomide — Drug Intelligence | 59 EU Trials

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59 Registered trials

33 Recruiting

14 Completed trials

46 Sponsors

23 Countries

Phase III

Phase II

Phase I/II

Phase III: 16 Phase II/III: 4 Phase II: 22 Phase I/II: 14 Phase I (FiH): 3

Oversight events:

11 temporary halts across 2 trials

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Indications tested

Glioblastoma 11 Neuroblastoma 3 Glioma 3 Glioblastoma multiforme 3 Rhabdomyosarcoma 2 Ewing's sarcoma 2 Medulloblastoma 2 Ewing´s sarcoma metastatic 1 Gastroenteropancreatic neuroendocrine tumour disease 1 Malignant glioma 1 Bladder cancer 1 Colorectal cancer stage II 1

Sponsors using this IMP

The University Of Birmingham 5 Bristol-Myers Squibb Services Unlimited Company 3 Eli Lilly & Co. 3 Institut Gustave Roussy 3 Centre Oscar Lambret 2 Fondazione IRCCS Istituto Nazionale Dei Tumori 2 Ifom Istituto Fondazione Di Oncologia Molecolare Ets In Breve Ifom Ets 2 Oslo University Hospital HF 2 Assistance Publique Hopitaux De Paris 1 AstraZeneca AB 1 Azienda Ospedaliera Universitaria Meyer IRCCS 1 Carthera 1

All trials

59 total

Multisite open-label randomized phase II clinical trial in newly diagnosed glioblastoma treated by concurrent TemoRadiation and adjuvant tem… Pending

2024-511880-27-00 Phase II 2 countries Assistance Publique Hopitaux De Paris
EVALUATION OF UCPVAX VACCINE +/- PEMBROLIZUMAB COMBINED WITH STANDARD TREATMENT AS ADJUVANT THERAPY IN PATIENTS WITH UNMETHYLATED GLIOBLASTO… Pending

2024-514399-42-00 Phase II 1 country Centre Hospitalier Regional Universitaire
BEACON 2: A Multi-Arm, Multi-Stage Platform Trial For Relapsed Neuroblastoma Pending

2024-516115-24-00 Phase I/II 10 countries The University Of Birmingham
A study to evaluate the safety and efficacy of the tumor-targeting human antibody-cytokine fusion protein L19TNF plus standard temozolomide … Pending

2024-516357-46-00 Phase I/II 2 countries Philogen S.p.A.
Quality of life and neurocognitive functioning in diffuse low-grade glioma patients treated with Temozolomide: feasibility study - TEMOIN Pending

2024-516918-37-00 Phase II 1 country Institut Regional Du Cancer De Montpellier
FIDES: Focused Ultrasound-mediated Blood-Brain Barrier Opening In Pontine Diffuse Midline Glioma (DMG) to Enhance Systemic Therapy with Temo… Pending

2025-520814-78-00 Phase I/II 1 country Universitair Medisch Centrum Utrecht
The MAYA2 trial Pending

2025-521941-25-00 Phase II 1 country Odense University Hospital
Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) Pending

2025-523389-26-00 Phase III 8 countries Deciphera Pharmaceuticals Inc.
First adjuvant trial in locally resected aggressive pancreatic neuroendocrine tumors: a randomized phase III investigating the efficacy of s… Pending

2025-523593-16-00 Phase III 1 country Institut Gustave Roussy
A study of BMS-986504 as Monotherapy and in Combination with Other Agents in Participants with Advanced and/or Metastatic Solid Tumors with … Pending

2025-524285-18-00 Phase II 2 countries Bristol-Myers Squibb Services Unlimited Company
An experimental trial to learn about hu14.18K322A treatment in children and adolescents with high-risk neuroblastoma. Pending

2025-524397-42-00 Phase II/III 5 countries Renaissance Pharma Limited
SUPRAME - ACTengine® IMA203 vs. investigator’s choice of treatment in previously treated, unresectable or metastatic cutaneous melanoma Recruiting

2024-517062-42-00 Phase III 3 countries Immatics US Inc.
A study comparing niraparib with temozolomide in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma Recruiting

2024-513077-48-00 Phase III 8 countries Neurotrials LLC
A RANDOMIZED, OPEN-LABEL PHASE 3 STUDY IN PATIENTS WITH PREVIOUSLY TREATED UNRESECTABLE OR METASTATIC NRAS MUTANT CUTANEOUS MELANOMA COMPARI… Recruiting

2024-511404-17-00 Phase III 10 countries Erasca Inc.
Tarlatamab vs standard of care chemotherapy in patients with pre-treated advanced, pulmonary or gastroenteropancreatic poorly differentiated… Recruiting

2024-515948-23-00 Phase III 1 country Intergroupe Francophone De Cancerologie Thoracique
Efficacy and Safety of Lisocabtagene Maraleucel (liso-cel) as First-Line Therapy in Adults with Transplant-Ineligible Primary Central Nervou… Recruiting

2025-521144-38-00 Phase II 2 countries Bristol-Myers Squibb Services Unlimited Company
TARLATEM : Combination of TARLAtamab and TEMozolomide in patients with central nervous system tumors. A multicenter, open-label Phase I/II t… Recruiting

2023-510568-11-00 Phase I/II 1 country Centre Leon Berard
A Study to Compare Vusolimogene oderparepvec (VO) Plus Nivolumab With the Doctor's Choice of Treatment in People With Skin Cancer That has G… Recruiting

2023-508612-29-00 Phase III 6 countries Replimune Inc.
A phase I/II trial of ABTL0812 in children with relapsed/refractory neuroblastoma and other solid tumours Recruiting

2023-504246-64-02 Phase I/II 1 country Fir Huvh Fundacio Institut De Recerca Hospital Universitari Vall De Hebron
A study in newly diagnosed glioblastoma patients that aims at testing the efficacy of Optune (Tumor Treating Fields), together with temozolo… Recruiting

2024-513550-30-00 Phase III 6 countries Novocure GmbH
Precision cancer medicine in hard-to-treat rare cancers - repurposing drugs in earlier lines of treatment - MATRIX-RARE. Recruiting

2024-513779-42-02 Phase II 1 country Oslo University Hospital HF
Phase III trial of lomustine/temozolomide (TMZ) combination therapy vs. standard TMZ therapy for newly diagnosed MGMT promoter methylated gl… Recruiting

2023-506998-35-00 Phase III 4 countries Region Oestergoetland; Vaestra Goetalandsregionen
HR-NBL2: High-risk neuroblastoma study 2.0 of SIOP-Europe- Neuroblastoma/SIOPEN: Randomised, international and multicentric phase 3 study t… Recruiting

2024-514917-36-00 Phase III 13 countries Institut Gustave Roussy
Oxidative Phosphorylation Targeting In Malignant glioma Using Metformin plus radiotherapy temozolomide Recruiting

2024-511026-31-01 Phase II 1 country Hospital Foch

Showing 1–24 of 59 trials

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